General model for depth-resolved estimation of the optical attenuation coefficients in optical coherence tomography
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Journal of Biophotonics
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We present the proof of concept of a
general model that uses the tissue
sample transmittance as input to estimate
the depth-resolved attenuation
coefficient of tissue samples using
optical coherence tomography (OCT). This method allows us to obtain an image of
tissue optical properties instead of intensity contrast, guiding diagnosis and tissues
differentiation, extending its application from thick to thin samples. The performance
of our method was simulated and tested with the assistance of a home built
single-layered and multilayered phantoms (~100 μm each layer) with known attenuation
coefficient on the range of 0.9 to 2.32 mm−1. It is shown that the estimated
depth-resolved attenuation coefficient recovers the reference values, measured by
using an integrating sphere followed by the inverse adding doubling processing
technique. That was corroborated for all situations when the correct transmittance
value is used with an average difference of 7%. Finally, we applied the proposed
method to estimate the depth-resolved attenuation coefficient for a thin biological
sample, demonstrating the ability of our method on real OCT images.
Como referenciar
AMARAL, MARCELLO M.; ZEZELL, DENISE M.; MONTE, ADAMO F.G.; CARA, ANA C.B. de; ARAUJO, JEANN C.R.; ANTUNES, ANDREA; FREITAS, ANDERSON Z. General model for depth-resolved estimation of the optical attenuation coefficients in optical coherence tomography. Journal of Biophotonics, v. 12, n. 10, p. 1-13, 2019. DOI: 10.1002/jbio.201800402. Disponível em: http://repositorio.ipen.br/handle/123456789/30433. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.