Pro-apoptotic effects of amblyomin-X in murine renal cell carcinoma 'in-vitro'
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Biomedicine and Pharmacotherapy
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Renal cell carcinoma (RCC) is one of the most lethal urologic cancers and is highly resistant to both
radiotherapy and chemotherapy. The recombinant protein Amblyomin-X, characterized as a Kunitz-type
protease inhibitor, was obtained from a cDNA library from the salivary glands of the Amblyomma
cajennense tick. This paper reports the biological effect of Amblyomin-X on inducing cell death by
apoptotic process in vitro. For this purpose, the changes in morphological aspects of cells, the
phosphatidylserine exposition and DNA degradation were evaluated after treatment with Amblyomin-
X. We found that Amblyomin-X was able to induce apoptosis in Renca cells in a dose-dependent manner.
So, the results presented here open perspectives for new researches and developing for Amblyomin-X in
the treatment of RCC.
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AKAGI, ERICA M.; SA JUNIOR, PAULO L. de; SIMONS, SIMONE M.; BELLINI, MARIA H.; BARRETO, SANDRA A.; CHUDZINSKI-TAVASSI, ANA M. Pro-apoptotic effects of amblyomin-X in murine renal cell carcinoma 'in-vitro'. Biomedicine and Pharmacotherapy, v. 66, n. 1, p. 64-69, 2012. DOI: 10.1016/j.biopha.2011.11.015. Disponível em: http://repositorio.ipen.br/handle/123456789/4296. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.