Risk evaluation of occupational exposure of southern Brazilian flower farmers to pesticides potentially leading to cholinesterase inhibition and metals exposure
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Environmental Toxicology and Pharmacology
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This work presents a frequency matched observational study comparing flower farmers exposed to pesticides and
unexposed individuals as controls. All subjects were interviewed before plasma and urine collection. Manganese
and Zinc were measured in theses samples by using dynamic reaction cell inductively coupled mass spectrometry.
Cholinesterase activity was analyzed through spectrophotometry by using a modified version of the Ellman
method. Seventy-eight percent of subjects reported occupational contact with pesticides, from which 37% reported
exposure for over 9 years. Flower farms farmers had increased odds of having headache and irritability,
respectively, by factors of 6.2 and 2.4 than the control subjects. While the odds of exposed subjects to have
insomnia was smaller than control subjects by a factor of 0.34. Exposure to pesticides had a significant effect
regarding the plasmatic plasma and urinary manganese levels and whole blood cholinesterase activity (p < 0.05).
High levels of plasma and urinary manganese, as well as cholinesterase inhibition in whole blood, were evident
in the flower farmers who participated in the study.
Como referenciar
AGUERA, RAUL G.; FREIRES, CAMILA da S.; OLIVEIRA, LUIS O. de; MONTEIRO, LUCILENA R.; LINI, RENATA S.; ROMOLI, JESSICA C.Z.; FREIRE, BRUNA M.; NERILO, SAMUEL B.; MACHINSKI JUNIOR , MIGUEL; BATISTA, BRUNO L.; MOSSINI, SIMONE A.G. Risk evaluation of occupational exposure of southern Brazilian flower farmers to pesticides potentially leading to cholinesterase inhibition and metals exposure. Environmental Toxicology and Pharmacology, v. 93, p. 1-9, 2022. DOI: 10.1016/j.etap.2022.103874. Disponível em: http://repositorio.ipen.br/handle/123456789/33172. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.