Analysis of the combined effects of resveratrol and radiation on lung cancer cells
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Top 25 Contributions on Cancer Research
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Mucoepidermoid lung carcinoma is frequently manifested by
obstructive trachea symptoms. It is necessary to develop effective curative
or palliative therapeutic strategies for treating mucoepidermoid
lung carcinoma through administration of compounds that improve
ionizing radiation treatment, thereby increasing the effects of the
treatment on tumor cells while minimizing the effects on normal tissues
surrounding the tumor cells. Resveratrol is a polyphenolic phytoalexin
present in wines and several plants and has a broad spectrum
of biological activities, including antioxidant and anticarcinogenic
effects. The biological effects of ionizing radiation plus resveratrol
have been examined in different types of cell in many studies. Here,
we aimed to verify the effects of resveratrol on mucoepidermoid
lung carcinoma cells NCI-H292 exposed to ionizing radiation. In
vitro studies in NCI-H292 cell culture using neutral red uptake assays
showed that the cytotoxicity index (IC50) of resveratrol was 401.5 μM,
and the lethal dose 50 % (LD50) of ionizing radiation in the absence
of resveratrol was 693 Gy. In vitro micronucleus assays were then performed
to verify the genotoxic effects of resveratrol, and fluorescence
assays were performed to evaluate the effects of resveratrol on the cell
cycle, repair and injury processes, cellular necrosis, and apoptosis.
The results demonstrated that 30 μM resveratrol promote injury on
NCI-H292 cells after 24 h of irradiation. Therefore, this study provides
results able to support in vitro future investigations about radiosensitive
potential of resveratrol in lung cancer cells. There is a need to
investigate compounds with potential to improve the local control of lung cancer promoted by radiation therapy. This way avoiding injuries
to healthy cells.
Como referenciar
MORENO, CAROLINA S.; ROGERO, SIZUE O.; GALISTEO JUNIOR, ANDRES J.; VIEIRA, DANIEL P.; CRUZ, AUREA S.; SAKURABA, ROBERTO K.; WELTMAN, EDUARDO; ROGERO, JOSE R. Analysis of the combined effects of resveratrol and radiation on lung cancer cells. In: WANG, JUE (ed.). Top 25 Contributions on Cancer Research. Telangana, India: Avid Science, 2019. , cap. 17. p. 2-27. (Avid Science Ebooks). Disponível em: http://repositorio.ipen.br/handle/123456789/29452. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.