Physicochemical and biological properties of nanohydroxyapatite grafted with star-shaped poly(ε-caprolactone)

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dc.contributor.authorKAIRALLA, ELENI C.pt_BR
dc.contributor.authorBRESSIANI, JOSE C.pt_BR
dc.contributor.authorBRESSIANI, ANA H. de A.pt_BR
dc.contributor.authorRIBELA, MARIA T. de C.P.pt_BR
dc.contributor.authorHIGA, OLGA Z.pt_BR
dc.contributor.authorQUEIROZ, ÁLVARO A.A. dept_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2023-01-23T18:22:48Z
dc.date.available2023-01-23T18:22:48Z
dc.date.issued2022pt_BR
dc.description.abstractTo overcome the disadvantages generated by the lack of interfacial bonding between hydroxyapatite nanocrystals (HAPN) and agglomeration of particles in the development of biodegradable nanocomposites a chemical grafting method was applied to modify the surface of HAPN through grafting of the three-arms star-shaped poly(ε-caprolactone) (SPCL) onto the nanoparticles. The chemical grafting of SPCL onto HAPN (SPCL-g-HAPN) has been investigated using Fourier transform infrared spectroscopy, thermogravimetric analysis, transmission electron microscopy (TEM), photoelectron spectroscopy, X-ray diffraction, zeta potential (ZP) and contact angle (CA). TEM micrographs of the SPCL-g-HAPN revealed the existence of hybrid organic/inorganic (O/I) nanoscale domains. The results of albumin (HSA) and fibrinogen (HFb) adsorption indicate resistance to HFb adsorption by SPCL-g-HAPN relatively to unmodified HAPN. The ZP and CA measurement suggest a heterogeneous topology for SPCL-g-HAPN likely due to the existence of hydrophobic-hydrophilic regions on the nanocomposite surface. The enzyme degradation by cholesterol esterase and lipase indicates that the rates of hydrolysis for SPCL-g-HAPN were very slow relative to the SPCL/HAPN blends. The in vitro biological studies showed that the human osteoblast-like cells (MG-63) cells had normal morphology and they were able to attach and spread out on SPCL-g-HAPN surfaces. A higher overall cellular proliferation was observed on SPCL-g-HAPN scaffolds compared to pure HAPN or SPCL materials.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipIDCNPq: 307609/2018-9pt_BR
dc.format.extent2353-2384pt_BR
dc.identifier.citationKAIRALLA, ELENI C.; BRESSIANI, JOSE C.; BRESSIANI, ANA H. de A.; RIBELA, MARIA T. de C.P.; HIGA, OLGA Z.; QUEIROZ, ÁLVARO A.A. de. Physicochemical and biological properties of nanohydroxyapatite grafted with star-shaped poly(ε-caprolactone). <b>Journal of Biomaterials Science, Polymer Edition</b>, v. 33, n. 18, p. 2353-2384, 2022. DOI: <a href="https://dx.doi.org/10.1080/09205063.2022.2104599">10.1080/09205063.2022.2104599</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/33655.
dc.identifier.doi10.1080/09205063.2022.2104599pt_BR
dc.identifier.fasciculo18pt_BR
dc.identifier.issn0920-5063pt_BR
dc.identifier.percentilfi50.3pt_BR
dc.identifier.percentilfiCiteScore65.5pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/33655
dc.identifier.vol33pt_BR
dc.relation.ispartofJournal of Biomaterials Science, Polymer Editionpt_BR
dc.rightsopenAccesspt_BR
dc.subjectorganic polymers
dc.subjectnanocrystals
dc.subjecthydroxy compounds
dc.subjectbiodegradation
dc.subjectnanocomposites
dc.subjectapatites
dc.subjectproteins
dc.subjectadsorption
dc.titlePhysicochemical and biological properties of nanohydroxyapatite grafted with star-shaped poly(ε-caprolactone)pt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorÁLVARO ANTONIO ALENCAR DE QUEIROZ
ipen.autorOLGA ZAZUCO HIGA
ipen.autorMARIA TERESA DE CARVALHO PINTO RIBELA
ipen.autorANA HELENA DE ALMEIDA BRESSIANI
ipen.autorJOSE CARLOS BRESSIANI
ipen.autorELENI CRISTINA KAIRALLA
ipen.codigoautor7319
ipen.codigoautor1023
ipen.codigoautor1197
ipen.codigoautor96
ipen.codigoautor1459
ipen.codigoautor6282
ipen.contributor.ipenauthorÁLVARO ANTONIO ALENCAR DE QUEIROZ
ipen.contributor.ipenauthorOLGA ZAZUCO HIGA
ipen.contributor.ipenauthorMARIA TERESA DE CARVALHO PINTO RIBELA
ipen.contributor.ipenauthorANA HELENA DE ALMEIDA BRESSIANI
ipen.contributor.ipenauthorJOSE CARLOS BRESSIANI
ipen.contributor.ipenauthorELENI CRISTINA KAIRALLA
ipen.date.recebimento23-01
ipen.identifier.fi3.6pt_BR
ipen.identifier.fiCiteScore6.4pt_BR
ipen.identifier.ipendoc29289pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi3.000 - 4.499
ipen.range.percentilfi50.00 - 74.99
ipen.type.genreArtigo
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sigepi.autor.atividadeQUEIROZ, ÁLVARO A.A. de:7319:810:Npt_BR
sigepi.autor.atividadeHIGA, OLGA Z.:1023:810:Npt_BR
sigepi.autor.atividadeRIBELA, MARIA T. de C.P.:1197:810:Npt_BR
sigepi.autor.atividadeBRESSIANI, ANA H. de A.:96:720:Npt_BR
sigepi.autor.atividadeBRESSIANI, JOSE C.:1459:720:Npt_BR
sigepi.autor.atividadeKAIRALLA, ELENI C.:6282:720:Spt_BR
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