A new 124Xe irradiation system for 123I production
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2023
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Applied Radiation and Isotopes
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Since 2001, Nuclear and Energy Research Institute IPEN-CNEN has produced weekly ultrapure iodine-123, using
a manual irradiation system, fully developed in IPEN. Iodine-123 radiopharmaceuticals have been produced and
distributed to hospitals and clinics of nuclear medicine, where several diagnostic imaging procedures for thyroid,
brain and cardiovascular functions are performed. Due to the short half-life and emission of low-energy photons,
this radioisotope becomes suitable for diagnosis in children. In the present work, the technical and constructive
aspects of a new fully automated irradiation system, dedicated to 123I routine production, employing enriched
xenon-124 gas as the target material is presented. This new system consists of a target, a water and helium
cooling system, a cryogenic system, an electric power system, and a control and process monitoring unit,
composed of supervisory software, connected to a programmable logic controller via personal computer. In this
new concept, there is no need for human intervention during radioisotope production, reducing the possibility of
eventual failures or incidents involving radioactive material. By using this new system, a specific yield of 2.70
mCi/μAh per irradiation was achieved in validation runs, and after three years of routine production of iodine-
123, the system showed reliability and resilience.
Como referenciar
COSTA, OSVALDO L. da; BARCELLOS, HENRIQUE; MATSUDA, HYLTON; SUMIYA, LUIZ C. do A.; JUNQUEIRA, FERNANDO de C.; MATSUDA, MARGARETH M.N.; LAPOLLI, ANDRE L. A new 124Xe irradiation system for 123I production. Applied Radiation and Isotopes, v. 200, p. 1-7, 2023. DOI: 10.1016/j.apradiso.2023.110926. Disponível em: http://repositorio.ipen.br/handle/123456789/34206. Acesso em: 15 Jun 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.