Plasma glucagon suppressibility after oral glucose in obese subjects with normal and impaired glucose tolerance
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Metabolism
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Blood glucose, plasma insulin, and glucagon responses after a 75 g oral glucose-tolerance test were assessed in 9 normal
controls, 5 obese nondiabetics (ON), 5 obese nondiabetics with fasting hyperinsulinemia (obese “resistant” nondiabetics-
OR), 9 obese with impaired glucose tolerance (O-IGT), and 9 nonobese insulin-dependent diabetics (IDD). Fasting plasma
glucagon concentrations were significantly higher in all groups of patients in comparison to the normal controls. Insulin
secretion, evaluated in all but the IDD, was similar to normal in the ON and increased in the OR and 0-IGT. Normal glucagon
suppression was observed in the lean controls and ON but not in OR, 0-IGT, and IDD. We suggested that the resistance to
glucagon suppression after glucose load in the OR and 0-IGT in the presence of increased insulin response could be an
indication that the A cell participates in the relative insulin insensitivity of these subjects.
Como referenciar
BORGHI, V.C.; WAJCHENBERG, B.L.; CESAR, F.P. Plasma glucagon suppressibility after oral glucose in obese subjects with normal and impaired glucose tolerance. Metabolism, v. 33, n. 12, p. 1068-1074, 1984. DOI: 10.1016/0026-0495(84)90089-1. Disponível em: http://repositorio.ipen.br/handle/123456789/26730. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.