Electrochemical preparation and characterization of PNIPAM-HAp scaffolds for bone tissue engineering
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Materials Science and Engineering C
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In the last decade, a variety of methods for fabrication of three-dimensional biomimetic scaffolds based on
hydrogels have been developed for tissue engineering. However, many methods require the use of catalysts
which compromises the biocompatibility of the scaffolds. The electrochemical polymerization (ECP) of acrylic
monomers has received an increased attention in recent years due to its versatility in the production of highly
biocompatible coatings for the electrodes used in medical devices. The main aim of this work was the use of ECP
as scaffold fabrication technique to produce highly porous poly(N-isopropylacrylamide) (PNIPAM)/hydroxyapatite
(HAp) composite for bone tissue regeneration. The prepared PNIPAM-HAp porous scaffolds were
characterized by SEM, FTIR, water swelling, porosity measurements and X-ray diffraction (XRD) techniques.
FTIR indicates that ECP promotes a successful conversion of NIPAM to PNIPAM. The water swelling and porosity
were shown to be controlled by the HAp content in PNIPAM-HAp scaffolds. The PNIPAM-HAp scaffolds exhibited
no cytotoxicity to MG63 cells, showing that ECP are potentially useful for the production of PNIPAMHAp
scaffolds. To address the osteomyelitis, a significant complication in orthopedic surgeries, PNIPAM-HAp
scaffolds were loaded with the antibiotic oxacillin. The oxacillin release and the bacterial killing activity of the
released oxacillin from PNIPAM-HAp against S. aureus and P. aeruginosa were demonstrated. These observations
demonstrate that ECP are promising technique for the production of non-toxic, biocompatible PNIPAM-HAp
scaffolds for tissue engineering.
Como referenciar
RIBEIRO, CHARLENE A.; MARTINS, MARCOS V.S.; BRESSIANI, ANA H.; BRESSIANI, JOSE C.; LEYVA, MARIA E.; QUEIROZ, ALVARO A.A. de. Electrochemical preparation and characterization of PNIPAM-HAp scaffolds for bone tissue engineering. Materials Science and Engineering C, v. 81, p. 156-166, 2017. DOI: 10.1016/j.msec.2017.07.048. Disponível em: http://repositorio.ipen.br/handle/123456789/27885. Acesso em: 29 Apr 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.