Octreotide nanoparticles showed affinity for in vivo MIA Paca-2 inducted pancreas ductal adenocarcinoma mimicking pancreatic polypeptide-secreting tumor of the distal pancreas (PPoma)
Carregando...
Data
Data de publicação
Autores IPEN
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
Pharmaceutical Research
ODS
Exportar
Resumo
Purpose Pancreatic Polypeptide-secreting tumor of the distal
pancreas (PPoma) is a rare, difficult and indolent type of cancer
with a survival rate of 5-year in only 10% of all cases. The
PPoma is classified as a neuroendocrine tumor (NET) not
functioning that overexpresses SSTR 2 (somatostatin receptor
subtype 2). Thus, in order to improve the diagnosis of this type
of tumor, we developed nanoparticulate drug carriers based
on poly-lactic acid (PLA) polymer loaded with octreotide and
radiolabeled with Technetium-99 m (99mTc).
Methods PLA/PVA octreotide nanoparticles were developed
by double-emulsion technique. These nanoparticles
were characterized by Atomic Force Microscopy (AFM) and
Dynamic Light Scattering (DLS) and radiolabeled with
99mTc by the direct via forming 99mTc-PLA/PVA octreotide
nanoparticles. The safety of these nanosystems was evaluated
by the MTT cell toxicity assay and their in vivo biodistribution
was evaluated in xenografted inducted animals.
Results The results showed that a 189 nm sized nanoparticle
were formed with a PDI of 0,097, corroborating the
monodispersive behavior. These nanoparticles were successfully radiolabeled with 99mTc showing uptake by the
inducted tumor. The MTT assay corroborated the safety of
the nanosystem for the cells.
Conclusion The results support the use of this nanosystem
(99mTc-PLA/PVA octreotide nanoparticles) as imaging agent
for PPoma.
Como referenciar
BRAGA, THAIS L.; PINTO, SUYENE R.; REIS, SARA R.R. dos; PORTILHO, FILIPE L.; BARROS, ALINE O. da S. de; BERNARDES, EMERSON S.; SANTOS, SOFIA N. dos; ALENCAR, LUCIANA M.R.; RICCI-JUNIOR, EDUARDO; SANTOS-OLIVEIRA, RALPH. Octreotide nanoparticles showed affinity for in vivo MIA Paca-2 inducted pancreas ductal adenocarcinoma mimicking pancreatic polypeptide-secreting tumor of the distal pancreas (PPoma). Pharmaceutical Research, v. 36, n. 10, p. 1-8, 2019. DOI: 10.1007/s11095-019-2678-4. Disponível em: http://repositorio.ipen.br/handle/123456789/30459. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.