Radiolytic synthesis of non-toxic, size-homogeneous gold nanoparticles
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2018
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CONGRESSO BRASILEIRO DE ENGENHARIA E CIÊNCIA DOS MATERIAIS, 23.
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Radiolytic synthesis of nanoparticles is one of the successful examples of Green
Chemistry (the use of non-toxic chemicals, environmentally benign solvents and
renewable materials during the chemical processes), in which the reducing agents
responsible for the particle nucleation are no other than the reactive species generated
by the radiolysis of the solvent itself (i.e. water, acetone or alcohols). This study
consists on the radiolytic synthesis and characterization of gold nanoparticles, as well
as the assessment of their toxicity levels to Zebrafish embryos (Danio rerio), as an
indication of a possible environmental effect. The nanoparticles were synthesized by
mixing: NaAuCl4 2 x 10-3 M; polyvinylpyrrolidone 100 kDa 0.5% (as size stabilizer);
propan-2-ol 0.2 M and acetone 0.06 M (for the generation of propyl radicals); and
AgNO3 6 x 10-5 M (another size stabilizer), followed by 10 kGy of gamma radiation (5
kGy h-1) [1]. The particles were characterized by their absorption spectra in the UV
and visible, and the dynamic light scattering (DLS) technique was used to assess their
hydrodynamic size. Finally, the impact on the development of Zebrafish embryos was
investigated for different dilutions of the nanoparticles suspension, according to the
OECD protocol nº 236 (Guideline on Fish Embryo Acute Toxicity Test – FET), as a
means of assessing the environmental impact of the nanomaterial. An acute (96 hours
of exposition to gold nanoparticles) and a chronic (168 hours of exposition) assay were
performed. The particles were successfully synthesized in a multipurpose gamma
irradiator, with an absorption peak at 532 nm and a narrow size distribution (around 80
nm). There was no evident toxicity for the fish in any tested concentration, leading to
the conclusion that this green method of nanoparticle synthesis generates a potentially
environment-safe material, with good control of size and optical properties.
Como referenciar
FREITAS, L.F. de; CAVALCANTE, A.K.; LUGAO, A.B. Radiolytic synthesis of non-toxic, size-homogeneous gold nanoparticles. In: CONGRESSO BRASILEIRO DE ENGENHARIA E CIÊNCIA DOS MATERIAIS, 23., 04-08 de novembro, 2018, Foz do Iguaçu, PR. Resumo... p. 6984-6984. Disponível em: http://repositorio.ipen.br/handle/123456789/29622. Acesso em: 04 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.