Exploring the release of Acyclovir from chitosan-based microstructured systems
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2024
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BRAZIL MRS MEETING, 22nd
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Resumo
Herpes simplex virus (HSV) infections is endemic worldwide and a frequent public health
concern [1], configuring one of the most prevalent in the world with 640,000 new cases/year
in Brazil [2]. Acyclovir, the drug which acts inhibiting its viral DNA polymerase, requires
frequent application to achieve the desired efficacy, due to its low permeation. In this
context, the use of biomaterials such as chitosan as a carrier is an alternative, once can
improve permeation and avoid toxic effects [3]. In this work, chitosan-based membranes,
capsules, and membrane/capsule microstructures were produced, characterized, and used
for Acyclovir encapsulation/release. The membranes and capsules were produced using the
casting and ionotropic crosslinking techniques, respectively. The physicochemical and
mechanical microstructures properties were obtained, and release tests were performed.
The better stability in drug encapsulation were observed for capsules and
membrane/capsules systems. Regarding to release assay, the membrane/capsules system
modulates the acyclovir release in 1 hour and 20 minutes, with peak concentration at 2
hours, meanwhile, the membrane and capsule systems, presented a conventional release
profile with all drug concentration being released in 15 - 20 minutes. All obtained structures
are promising to act as conventional and controlled release systems. The differential of
these microstructures is the combination of healing properties, tissue repair,
biocompatibility, biodegradability, and physicochemical and mechanical properties
evaluated, associated with the selective action of the Acyclovir in the treatment of lesions
caused by the HSV.
Como referenciar
SILVA, BRUNO B. da; MENEZES, JORGE E.; COSTA, MARDOQUEU M. da; SANTOS, LAURITA dos; SANFELICE, RAFAELA C.; PAVINATTO, ADRIANA; SILVA, PAULO S.C. da. Exploring the release of Acyclovir from chitosan-based microstructured systems. In: BRAZIL MRS MEETING, 22nd, September 29 - October 3, 2024, Santos, SP. Abstract... São Carlos, SP: Aptor Software, 2024. p. 626-626. Disponível em: https://repositorio.ipen.br/handle/123456789/48943. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.