Prostate tumor therapy advances in nuclear medicine
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Journal of Radioanalytical and Nuclear Chemistry
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We report herein an innovative approach to prostate tumor therapy using tumor specific radioactive gold nanoparticles
(198Au) functionalized with Mangiferin (MGF). Production and full characterization of MGF-198AuNPs are described. In vivo
therapeutic efficacy of MGF-198AuNPs, through intratumoral delivery, in SCID mice bearing prostate tumor xenografts
are described. Singular doses of the nano-radiopharmaceutical (MGF-198AuNPs) resulted in over 85% reduction of tumor
volume as compared to untreated control groups. The excellent anti-tumor efficacy of MGF-198AuNPs are attributed to the
retention of over 90% of the injected dose within tumors for long periods of time. The retention of MGF-198AuNPs is also
rationalized in terms of the higher tumor metabolism of glucose which is present in the xanthanoid functionality of MGF.
Limited/no lymphatic drainage of MGF-198AuNPs to various non-target organs is an attractive feature presenting realistic
scope for the clinical translation of MGF-198AuNPs in for treating prostate cancers in human patients. The comparative
analysis of MGF-198AuNPs with other radioactive gold nanoparticles, functionalized either with epigallocatechin gallate
or the Gum Arabic, has revealed significantly superior tumoricidal characteristics of MGF-198AuNPs, thus corroborating
the importance of the tumor-avid glucose motif of MGF. Oncological implications of MGF-198AuNPs as a new therapeutic
agent for treating prostate and various solid tumors are presented.
Como referenciar
KATTI, K.V.; KHOOBCHANDANI, M.; THIPE, V.C.; AL-YASIRI, A.Y.; KATTI, K.K.; LOYALKA, S.K.; SAKR, T.M.; LUGAO, A.B. Prostate tumor therapy advances in nuclear medicine: green nanotechnology toward the design of tumor specific radioactive gold nanoparticles. Journal of Radioanalytical and Nuclear Chemistry, v. 318, n. 3, p. 1737-1747, 2018. DOI: 10.1007/s10967-018-6320-4. Disponível em: http://repositorio.ipen.br/handle/123456789/29425. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.