Conceptual proposal of a facility design for accommodating minipigs for pharmaceutical and radiopharmaceutical research
Carregando...
Data
Data de publicação
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
Journal of Civil Engineering and Architecture
Exportar
Resumo
The use of Animal House Facilities of IPEN-CNEN/SP (Nuclear and Energetic Research Institute—National Nuclear
Energy Commission/SP, Brazil) has provided rats and mice with controlled sanitary quality for research and quality control in the
production of radiopharmaceuticals lots, produced at IPEN, following rules of CONCEA—Brazilian National Council for Animal
Experimentation Control and approved in CEUA (Ethics Committee on the Use of Animals), before they are sent to hospitals and
clinics spread out in Brazil, for use in nuclear medicine. The production and the supply of high quality laboratory animals have
fundamental importance for the accomplishment of vanguard scientific research, with reproducibility and universality. The quality of
those animals depends, largely, on the available facilities for their production and lodging, to assure the demanded sanitary control and
animal’s welfare, in agreement with the ethical principles that control the activity. Therefore, the facilities design is of vital importance
so that the mentioned requirements can be reached. Nevertheless, pigs and miniature pigs have gained importance as large animal
models in medicine. With their size, organ capacity, and physiology resembling in several aspects that of humans, pigs are well suited
for preclinical experiments and long-term safety studies. Minipigs will be used for preclinical testing of radiopharmaceuticals and
assays radioactive materials for cardiac tests. This paper describes the premises and preliminary activities that have been performed at
IPEN for the design of new Animal House Facilities dedicated to keeping minipigs taking into account fundamental aspects such as:
animal’s welfare, sanitation, genetic, in agreement with the ethical principles that control the activity and environmental concerns.
Como referenciar
LAINETTI, ELIZABETH B.F.; PASSOS, LUIZ A.C.; SOARES, CARLOS R.J.; NASCIMENTO, NANCI do. Conceptual proposal of a facility design for accommodating minipigs for pharmaceutical and radiopharmaceutical research. Journal of Civil Engineering and Architecture, v. 10, p. 881-887, 2016. DOI: 10.17265/1934-7359/2016.08.003. Disponível em: http://repositorio.ipen.br/handle/123456789/27149. Acesso em: 31 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.