Betalactamic antibiotics monitoring by Raman/SERS spectroscopy using non-conventional nanoparticles
Carregando...
Data
Data de publicação
2024
Autores IPEN
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
É parte de
BRAZIL MRS MEETING, 22nd
Exportar
Resumo
Various analytical techniques, including gas chromatography, electrochemical
immunosensors have been documented to identify and characterize molecules with
biological significance, like antibiotics, which is crucial in biomedicine. The surveillance of
drug usage in intensive care units proves pivotal in combating of infectious ailments,
notably antibiotic-resistant bacteria, a significant challenge in global healthcare [1].
However, many methods demand substantial reagents, utilize costly equipment, and
frequently consume considerable time. There is a need to devise inexpensive, rapid, and
sensitive detection methods. Optical-based approaches like Raman spectroscopy and
Surface-Enhanced Raman Scattering (SERS) present promising avenues for such diagnostic
technologies [2]. Furthermore, ample opportunity exists for research into alternative
materials, such as post-transition metals, to be employed in this domain (beyond Ag and Au
nanoparticles (NP)) [3]. Using laser-generated NP as substrate materials, we present results
on SERS for the monitoring of beta-lactam drugs (class of antibiotics that have beta-lactam
ring, which imparts bactericidal activity), which are commonly prescribed in critically ill
patients, being this the most important class of antibiotics. Our Raman experiments were
performed by mixing aqueous solutions of antibiotics with several elements’ NP (Au, Co, Cu,
V). Ampicillin, Ceftazidime, and Meropenem were tested for Raman/SERS. We demonstrate
the possibility of antimicrobial fingerprint identification, interesting vibrational peak
changes and intense enhancement of specific Raman peaks. All tested NP are potential
candidates for developing Raman/SERS biotests for molecular monitoring and
characterization of antimicrobial drugs.
Como referenciar
ANJOS, VINICIUS P. dos; MARANGONI, CAROLINE G.P. da S.; MACHADO, THIAGO N.; COSTA, LIBERA M.D.; SCHREINER, WIDO H.; GOES, RAFAEL E. de; BEZERRA JUNIOR, ARANDI G. Betalactamic antibiotics monitoring by Raman/SERS spectroscopy using non-conventional nanoparticles. In: BRAZIL MRS MEETING, 22nd, September 29 - October 3, 2024, Santos, SP. Abstract... São Carlos, SP: Aptor Software, 2024. p. 696-696. Disponível em: https://repositorio.ipen.br/handle/123456789/48932. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.