Synthesis of high stable gold (198) nanoparticles for radiotherapy

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dc.contributor.authorSANTOS, JONNATAN J.
dc.contributor.authorLEAL, JESSICA
dc.contributor.authorDIAS, LUIS A.P.
dc.contributor.authorTOMA, SERGIO H.
dc.contributor.authorCORIO, PAOLA
dc.contributor.authorARAKI, KOITI
dc.contributor.authorGENEZINI, FREDERICO A.
dc.contributor.authorKATTI, KATTESH V.
dc.contributor.authorLUGAO, ADEMAR B.
dc.coverageInternacionalpt_BR
dc.creator.eventoPAN AMERICAN CONGRESS OF NANOTECHNOLOGY, 1stpt_BR
dc.date.accessioned2018-08-14T10:53:32Z
dc.date.available2018-08-14T10:53:32Z
dc.date.evento27-30 de novembro, 2017pt_BR
dc.description.abstractCancer has become a problem in the last years, is expect be diagnosed more than 500 000 new cases in 2017, only in Brazil, according to Brazilian Cancer Nacional Institute. Among women breast cancer is the most common and among men the most representative is prostate cancer, and although treatments for both cancers have been already developed, new methods more efficient and that causes less damage to the patient are always being searched. Gold nanoparticles (AuNps) have many different applications on chemistry, biology, medicine, etc; their low reactivity and toxicity and high stability become it very interesting for bioapplications, such as drugs delivery and biosensing. In this work, we had developed a new method to prepare 198AuNps, from a leaf of gold bombed by neutrons, adapting Turkevich method, these nanoparticles were modified with bovine serum albumin (BSA) and characterized by multiple techniques, after 30 days (eleven half-life decays). This methodology was capable of generate AuNps with almost 14 nm and Zeta potential higher than -37 mV, very stable. BSA can be used for different applications, like a simple stabilizer or to increase cellular uptaking, but in our case its chromophore groups were utilized to follow damages caused by radiation, as a sensor for radiation damage, a dosimeter. Bellow are presented TEM image, Zeta potential measures and fluorescence spectroscopy of the 198AuNps-BSA samples.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 17/20177-3pt_BR
dc.event.siglaPANNANOpt_BR
dc.identifier.citationSANTOS, JONNATAN J.; LEAL, JESSICA; DIAS, LUIS A.P.; TOMA, SERGIO H.; CORIO, PAOLA; ARAKI, KOITI; GENEZINI, FREDERICO A.; KATTI, KATTESH V.; LUGAO, ADEMAR B. Synthesis of high stable gold (198) nanoparticles for radiotherapy. In: PAN AMERICAN CONGRESS OF NANOTECHNOLOGY, 1st, 27-30 de novembro, 2017, Guarujá, SP. <b>Abstract...</b> Disponível em: http://repositorio.ipen.br/handle/123456789/29055.
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.orcidhttps://orcid.org/0000-0002-6318-6805
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/29055
dc.local.eventoGuarujá, SPpt_BR
dc.rightsopenAccesspt_BR
dc.titleSynthesis of high stable gold (198) nanoparticles for radiotherapypt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorJESSICA LEAL
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorFREDERICO ANTONIO GENEZINI
ipen.autorLUIS ALBERTO PEREIRA DIAS
ipen.autorJONNATAN JULIVAL DOS SANTOS
ipen.codigoautor11679
ipen.codigoautor339
ipen.codigoautor2045
ipen.codigoautor796
ipen.codigoautor14395
ipen.contributor.ipenauthorJESSICA LEAL
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorFREDERICO ANTONIO GENEZINI
ipen.contributor.ipenauthorLUIS ALBERTO PEREIRA DIAS
ipen.contributor.ipenauthorJONNATAN JULIVAL DOS SANTOS
ipen.date.recebimento18-08pt_BR
ipen.event.datapadronizada2017pt_BR
ipen.identifier.ipendoc24847pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
relation.isAuthorOfPublication4718f72f-9574-4e63-8272-371bfddc8de6
relation.isAuthorOfPublication99ac24c5-2ae1-465a-a6f2-40b4d9af6af7
relation.isAuthorOfPublication0c41d307-45a9-47c4-8281-5aa9ed46e6a4
relation.isAuthorOfPublication50b3adab-a651-4225-a05c-ec1b1e37e921
relation.isAuthorOfPublicationc7b4987e-3364-4802-b86a-be5795156c8d
relation.isAuthorOfPublication.latestForDiscoveryc7b4987e-3364-4802-b86a-be5795156c8d
sigepi.autor.atividadeSANTOS, JONNATAN J.:14395:740:Spt_BR
sigepi.autor.atividadeLEAL, JESSICA:11679:740:Npt_BR
sigepi.autor.atividadeDIAS, LUIS A.P.:796:110:Npt_BR
sigepi.autor.atividadeGENEZINI, FREDERICO A.:2045:310:Npt_BR
sigepi.autor.atividadeLUGAO, ADEMAR B.:339:740:Npt_BR
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