Experimental design and bioassays as tools to investigate the impact of anodic oxidation on progestins degradation

Página do item simplificado
dc.contributor.authorJESUS, JULIANA M.S. dept_BR
dc.contributor.authorARGOLO, ALLAN dos S.pt_BR
dc.contributor.authorTOMINAGA, FLAVIO K.pt_BR
dc.contributor.authorTAQUEDA, MARIA E.pt_BR
dc.contributor.authorBILA, DANIELE M.pt_BR
dc.contributor.authorBORRELY, SUELI I.pt_BR
dc.contributor.authorTEIXEIRA, ANTONIO C.S.C.pt_BR
dc.coverageInternacional
dc.date.accessioned2023-04-26T12:26:54Z
dc.date.available2023-04-26T12:26:54Z
dc.date.issued2023pt_BR
dc.description.abstractThe present study investigated the degradation of levonorgestrel (LNG) and gestodene (GES) through an anodic oxidation process mediated by active chlorine species. The independent variables [LNG]0 and [GES]0, current density (mA cm−2), and [NaCl]0 (mol L−1) were optimized through a response surface methodology (RSM) based on a four-level central composite design (CCD). Specific energy consumption allowed CCD-RSM analysis and optimization. The decay of progestins was followed to verify the kinetics of the anodic degradation process. Chlorine monitoring showed that excess Cl− concentration did not mean high hormones removal, as well as the excess of current density. Central point conditions ([NaCl]0 = 0.07 mol L−1, j = 32.5 mA cm−2, [LNG]0, and [GES]0 1.0 mg L−1) proved to be the best operational option. The performance with real pharmaceutical wastewater confirmed model optimization (2.2 ± 0.2 kWh g−1, with removals of 83.1 ± 0.9% and 75.1 ± 2.8% for LNG and GES, respectively). The selected condition was used for estrogenic activity and acute toxicity assays. The first allowed the identification of the initial estrogenic activity for the mixture of LNG and GES (924 E2-EQ ng L−1). Additionally, the electrochemical process could decrease this environmental parameter by 74.6%. The progestin mixture was classified as acute toxicity to Daphnia similis, with a toxicity unit (TU) of 2.5 100/EC50%. After electrolysis, the hormone solutions reached a fourfold increase in TU value, classified as high acute toxicity.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipIDCAPES: 001pt_BR
dc.description.sponsorshipIDFAPESP: 19/24158-9pt_BR
dc.description.sponsorshipIDCNPq: 311230/2020-2pt_BR
dc.format.extent1-18pt_BR
dc.identifier.citationJESUS, JULIANA M.S. de; ARGOLO, ALLAN dos S.; TOMINAGA, FLAVIO K.; TAQUEDA, MARIA E.; BILA, DANIELE M.; BORRELY, SUELI I.; TEIXEIRA, ANTONIO C.S.C. Experimental design and bioassays as tools to investigate the impact of anodic oxidation on progestins degradation. <b>Water</b>, v. 15, n. 1, p. 1-18, 2023. DOI: <a href="https://dx.doi.org/10.3390/w15010061">10.3390/w15010061</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/34006.
dc.identifier.doi10.3390/w15010061pt_BR
dc.identifier.fasciculo1pt_BR
dc.identifier.issn2073-4441
dc.identifier.orcidhttps://orcid.org/0000-0002-9692-5539
dc.identifier.percentilfi60.9
dc.identifier.percentilfiCiteScore74.00
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/34006
dc.identifier.vol15pt_BR
dc.relation.ispartofWater
dc.rightsopenAccesspt_BR
dc.subjectcomposite materials
dc.subjectdesign
dc.subjectprogesterone
dc.subjectwaste water
dc.subjectdrugs
dc.subjectestrogens
dc.subjecthormones
dc.subjectwater pollution
dc.titleExperimental design and bioassays as tools to investigate the impact of anodic oxidation on progestins degradationpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorSUELI IVONE BORRELY
ipen.autorFLAVIO KIYOSHI TOMINAGA
ipen.codigoautor150
ipen.codigoautor12754
ipen.contributor.ipenauthorSUELI IVONE BORRELY
ipen.contributor.ipenauthorFLAVIO KIYOSHI TOMINAGA
ipen.date.recebimento23-04
ipen.identifier.fi3.0
ipen.identifier.fiCiteScore5.8
ipen.identifier.ipendoc29630
ipen.identifier.iwosWoSpt_BR
ipen.identifier.ods6
ipen.range.fi3.000 - 4.499
ipen.range.percentilfi50.00 - 74.99
ipen.type.genreArtigo
relation.isAuthorOfPublication76171e20-c8ac-475f-9006-27402113c92f
relation.isAuthorOfPublicationaa4a15b8-4ad7-4bb6-a280-c0de5cf947d6
relation.isAuthorOfPublication.latestForDiscoveryaa4a15b8-4ad7-4bb6-a280-c0de5cf947d6
sigepi.autor.atividadeBORRELY, SUELI I.:150:220:Npt_BR
sigepi.autor.atividadeTOMINAGA, FLAVIO K.:12754:220:Npt_BR
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
29630.pdf
Tamanho:
1.68 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar
Coleções
Periódicos