Colorectal cancer chemoprevention by 2 'Beta'-cyclodextrin inclusion compounds of auraptene and 4'-geranyloxyferulic acid
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International Journal of Cancer
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The inhibitory effects of novel prodrugs, inclusion complexes of 3-(40
-geranyloxy-30
-methoxyphenyl)-2-trans propenoic acid
(GOFA) and auraptene (AUR) with b-cyclodextrin (CD), on colon carcinogenesis were investigated using an azoxymethane (AOM)/
dextran sodium sulfate (DSS) model. Male CD-1 (ICR) mice initiated with a single intraperitoneal injection of AOM (10 mg/kg
body weight) were promoted by the addition of 1.5% (w/v) DSS to their drinking water for 7 days. They were then given a basal
diet containing 2 dose levels (100 and 500 ppm) of GOFA/b-CD or AUR/b-CD for 15 weeks. At Week 18, the development of
colonic adenocarcinoma was significantly inhibited by feeding with GOFA/b-CD at dose levels of 100 ppm (63% reduction in
multiplicity, p < 0.05) and 500 ppm (83% reduction in the multiplicity, p < 0.001), when compared with the AOM/DSS group
(multiplicity: 3.36 6 3.34). In addition, feeding with 100 and 500 ppm (p < 0.01) of AUR/b-CD suppressed the development of
colonic adenocarcinomas. The dietary administration with GOFA/b-CD and AUR/b-CD inhibited colonic inflammation and also
modulated proliferation, apoptosis and the expression of several proinflammatory cytokines, such as nuclear factor-kappaB,
tumor necrosis factor-a, Stat3, NF-E2-related factor 2, interleukin (IL)-6 and IL-1b, which were induced in the adenocarcinomas.
Our findings indicate that GOFA/b-CD and AUR/b-CD, especially GOFA/b-CD, are therefore able to inhibit colitis-related colon
carcinogenesis by modulating inflammation, proliferation and the expression of proinflammatory cytokines in mice.
Como referenciar
TANAKA, TAKUJI; AZEVEDO, MARIANGELA B.M.; DURAN, NELSON; ALDERETE, JOEL B.; EPIFANO, FRANCESCO; GENOVESE, SALVATORE; TANAKA, MAYU; TANAKA, TAKAHIRO; CURINI, MASSIMO. Colorectal cancer chemoprevention by 2 'Beta'-cyclodextrin inclusion compounds of auraptene and 4'-geranyloxyferulic acid. International Journal of Cancer, v. 126, n. 4, p. 830-840, 2010. DOI: 10.1002/ijc.24833. Disponível em: http://repositorio.ipen.br/handle/123456789/8051. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.