The effects gamma radiation dose on the swelling capacity of PVP/lignin hydrogels dressings for wound treatment
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2019
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WORKSHOP DE BIOMATERIAIS, ENGENHARIA DE TECIDOS E ORGÃOS ARTIFICIAIS, 6th
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Lignin is a carbon renewable source and has been widely explored in different areas in the last
years, especially in the biomaterials field as dressings and other biomedical devices due its
natural origin and low cost (1). Its chemical structure confers important properties to this
macromolecule such as antioxidant capacity, UV protection and bactericidal activity (2,3).
Polivinylpirrolidone (PVP) is a polymer widely applied for biomedical applications due to its
relevant properties, such as the water absorption capacity, suitable mechanical properties for
wound healing applications, and the capacity to originate hydrogels with different characteristics
(4). Gamma radiation is a relevant option to produce biomedical devices, as the technology
allows polymer crosslinking and sterilization in a single step (5). Two polymer solutions were
prepared, PVP 10% (w, v) in distiled water (neutral pH) with poly(ethylene glycol) diacrylate
(1.0% w/v) and lignin 6% (w, v) (pH > 13) and homogenized separately, until complete
dissolution. The solutions were mixed in the follow ratios 95/5, 90/10 and 80/20, in which were
added to a 2% (w, v) of agar and mixed at 70 ºC for 30 minutes. Samples were disposed in glass
moulds and irradiated at 25, 50 and 100 kGy at dose rate of 5 kGy/h in a 60Co irradiator. Samples
assessed by autoclave presented higher swelling than the PVP control, but lower gel fraction in
comparison with the standard, except for formulation 90:10. Swelling and Gel Fraction were also
evaluated by shaker at 37 ºC for 24 h. The results showed that the increase of dose decrease
the swelling capacity and gel fraction decrease with the increase of lignin in the formulations. In
general, the hydrogels irradiated at 25 and 50 kGy, except for formulation 80:20 at 25 kGy,
presented good integrity and suitable results to be considered for the next steps of the study and
are promising for biomedical application.
Como referenciar
NOGUEIRA, K.M.; VARCA, J.O.; LIMA, C.S.A.; VARCA, G.; LUGAO, A.B.; FREITAS, L.F. The effects gamma radiation dose on the swelling capacity of PVP/lignin hydrogels dressings for wound treatment. In: WORKSHOP DE BIOMATERIAIS, ENGENHARIA DE TECIDOS E ORGÃOS ARTIFICIAIS, 6th, October 29-31, 2019, São Paulo, SP. Abstract... p. 246-246. Disponível em: http://repositorio.ipen.br/handle/123456789/31557. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.