Production of porous hydroxyapatite by the gel-casting of foams and cytotoxic evaluation
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Journal of Biomedical Materials Research
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This study presents the manufacture of highly
porous hydroxyapatite by a novel technique that employs
the foaming of suspensions prior to the in situ polymerization of organic monomers contained in the compositions.
This method produces strong gelled bodies with up to 90%
porosity that can withstand machining in the green state.
Complex-shaped components can be obtained if the process
comprises casting in one of the processing steps. The organic
additives are eliminated at temperatures above 300°C, and
sintering is carried out for consolidation of the ceramic matrix. Spherical interconnected cells with sizes ranging from
20 to 1000 mm characterize the porous structure, depending
on the specimen density. Cytotoxicity tests were conducted
on extracts from sintered HA foams based on a quantitative
method of cell colony formation and the determination of
cell death after indirect contact of the porous material with
mammalian cells. This in vitro test of biological evaluation
revealed that the original purity of the biomedical-grade hydroxyapatite powder was affected neither through processing nor by the employed reagents.
Como referenciar
SEPULVEDA, P.; BINNER, J.G.P.; ROGERO, S.O.; HIGA, O.Z.; BRESSIANI, J.C. Production of porous hydroxyapatite by the gel-casting of foams and cytotoxic evaluation. Journal of Biomedical Materials Research, v. 50, n. 1, p. 27-34, 2000. DOI: 10.1002/(SICI)1097-4636(200004)50:1<27::AID-JBM5>3.0.CO;2-6. Disponível em: http://repositorio.ipen.br/handle/123456789/7136. Acesso em: 30 Dec 2025.
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