Physical, chemical, and biological characterization of biodegradable chitosan dressing for biomedical applications
Carregando...
Data
Data de publicação
Autores IPEN
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
Materials Chemistry and Physics
Exportar
Resumo
Chitosan, a biomaterial with properties that allows the elaboration of biocompatible and biodegradable systems,
was employed to prepare dressings - 2% (w/v) in acetic acid - followed by freezing and lyophilization. Some
samples were kept chemically unchanged and used as control, while others were cross-linked with Epichlorohydrin 0.01 mol L− 1 for 24 h being washed, frozen and lyophilized. The neutralization procedure was performed
with sodium bicarbonate, which ended up leading to a crosslinking by ionic interactions in the polymer network,
and characteristics as promising as those of the chemically cross-linked with Epichlorohydrin. SEM showed that
the crosslinking leads to a controlled formation of the polymeric network, conferring suitable steam permeation
capacity 107 g mm.day− 1
.m− 2
.kPa− 1
, simulated fluid permeation between 2000 and 2500 g m− 2
.day-1 and
porosity with interconnection which allows fluid absorption capacity above 900%. The crosslinking processes
favored a better handling mechanical resistance confirmed by biodegradation assays. The dressing blocked
micro-organisms permeation, forming an efficient barrier against contamination, is safe and biocompatible,
allowing satisfactory cell adhesion and proliferation. These results showed that both dressings present statistically and satisfactory equivalent characteristics to be used as a functional bio dressing suitable for the treatment
of different pathologies.
Como referenciar
ERNESTO, JULIA V.; GASPARINI, ISIS de M.; CORAZZA, FULVIO G.; MATHOR, MONICA B.; SILVA, CLASSIUS F. da; LEITE-SILVA, VANIA R.; ANDREO-FILHO, NEWTON; LOPES, PATRICIA S. Physical, chemical, and biological characterization of biodegradable chitosan dressing for biomedical applications: could sodium bicarbonate act as a crosslinking agent?. Materials Chemistry and Physics, v. 301, p. 1-15, 2023. DOI: 10.1016/j.matchemphys.2023.127636. Disponível em: http://repositorio.ipen.br/handle/123456789/34079. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.