Protein crosslinking by high energy irradiation - towards the development of size-controlled biocompatible nanocarriers

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dc.contributor.authorVARCA, G.H.
dc.contributor.authorMOHAMED, L.B.
dc.contributor.authorFAZOLIN, G.N.
dc.contributor.authorOLIVEIRA, J.P.
dc.contributor.authorBATISTA, J.G.
dc.contributor.authorLUGAO, A.B.
dc.coverageInternacionalpt_BR
dc.creator.eventoCONGRESSO LATINO-AMERICANO DE ORGAOS ARTIFICIAIS E BIOMATERIAIS, 9; CONGRESSO DA SOCIEDADE LATINO AMERICANA DE BIOMATERIAIS, ORGAOS ARTIFICIAIS E ENGENHARIA DE TECIDOS, 13.pt_BR
dc.date.accessioned2017-05-19T14:06:51Z
dc.date.available2017-05-19T14:06:51Z
dc.date.evento24-27 de agosto, 2016pt_BR
dc.description.abstractProtein and peptide based delivery systems are on the spotlight considering their unique properties specially related to site specific delivery and high biocompatibility despite other biopharmaceutical advantages. Following the recent success of the so-called NAB platform, most of the attention has been driven towards the development of cosolvent -free or crosslinker-free technologies capable of producing protein nanoparticles with a specific size or shape, in the seek for better or preferential tumor uptake and low or negligible toxicity among other features. Within this context irradiation stands a tool capable of promoting protein crosslinking and sterilization of the systems simultaneously, in which combined or not with other techniques may allow the design of nanocarriers without the need of monomers or toxic crosslinkers. This research details the use of high energy irradiation towards the design of size-controlled protein-based nanocarriers for drug delivery. The albumin or papain based nanocarriers were designed by combining desolvation/solvation techniques followed by gamma irradiation or gamma irradiation alone. Sizecontrolled nanocarriers were manufactured up to 80 nm, as determined by dynamic light scattering, depending upon the protein or the presence of cosolvent. Nanocarrier morphology was evaluated by transmission electron microscopy, and protein crosslinking was evaluated by means of bityrosine formation using fluorescence measurements. Final applications of the developed systems comprise relevant potential for the delivery of radiopharmaceuticals or chemotherapic agents.pt_BR
dc.event.siglaSLABOpt_BR
dc.format.extent1162-1162pt_BR
dc.identifier.citationVARCA, G.H.; MOHAMED, L.B.; FAZOLIN, G.N.; OLIVEIRA, J.P.; BATISTA, J.G.; LUGAO, A.B. Protein crosslinking by high energy irradiation - towards the development of size-controlled biocompatible nanocarriers. In: CONGRESSO LATINO-AMERICANO DE ORGAOS ARTIFICIAIS E BIOMATERIAIS, 9; CONGRESSO DA SOCIEDADE LATINO AMERICANA DE BIOMATERIAIS, ORGAOS ARTIFICIAIS E ENGENHARIA DE TECIDOS, 13., 24-27 de agosto, 2016, Foz do Iguaçu, PR. <b>Abstract...</b> p. 1162-1162. Disponível em: http://repositorio.ipen.br/handle/123456789/27474.
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/27474
dc.local.eventoFoz do Iguaçu, PRpt_BR
dc.rightsopenAccesspt_BR
dc.titleProtein crosslinking by high energy irradiation - towards the development of size-controlled biocompatible nanocarrierspt_BR
dc.typeResumo de eventos científicospt_BR
dspace.entity.typePublication
ipen.autorLINA BADDIA MOHAMED
ipen.autorJOAO PEDRO DE OLIVEIRA FLORES
ipen.autorJORGE GABRIEL DOS SANTOS BATISTA
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorGABRIELA NEMESIO FAZOLIN
ipen.autorGUSTAVO HENRIQUE COSTAVARCA
ipen.codigoautor13998
ipen.codigoautor10625
ipen.codigoautor10274
ipen.codigoautor339
ipen.codigoautor14241
ipen.codigoautor8661
ipen.contributor.ipenauthorLINA BADDIA MOHAMED
ipen.contributor.ipenauthorJOAO PEDRO DE OLIVEIRA FLORES
ipen.contributor.ipenauthorJORGE GABRIEL DOS SANTOS BATISTA
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorGABRIELA NEMESIO FAZOLIN
ipen.contributor.ipenauthorGUSTAVO HENRIQUE COSTAVARCA
ipen.date.recebimento17-05pt_BR
ipen.event.datapadronizada2016pt_BR
ipen.identifier.ipendoc23778pt_BR
ipen.notas.internasAbstractpt_BR
ipen.type.genreResumo
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relation.isAuthorOfPublication.latestForDiscovery46f998cf-b207-4854-94c0-dd2def4eec2a
sigepi.autor.atividadeVARCA, G.H.:8661:750:Spt_BR
sigepi.autor.atividadeMOHAMED, L.B.:13998:750:Npt_BR
sigepi.autor.atividadeFAZOLIN, G.N.:14241:-1:Npt_BR
sigepi.autor.atividadeLUGAO, A.B.:339:740:Npt_BR
sigepi.autor.atividadeOLIVEIRA, J.P.:10625:-1:Npt_BR
sigepi.autor.atividadeBATISTA, J.G.:10274:740:N
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