Development of mucoadhesive PVA/CMC based hydrogel for intravesical chemotherapy
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2018
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CONGRESSO BRASILEIRO DE ENGENHARIA E CIÊNCIA DOS MATERIAIS, 23.
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Bladder cancer (BC) is one of the main diseases that attack the urinary tract and is
globally responsible for 165,000 deaths per year. Bladder tumor may be classified as
non-muscle invasive (superficial) or muscle invasive. About 70% of patients present
the superficial bladder cancer which is treated by transurethral resection for tumor
removal followed by intravesical chemo or immunotherapy. The main challenge
reported in the instillation of chemotherapy is the limited drug residence time in the
bladder as a consequence of urine levels that leads to fast drug removal from the
bladder.1 Hydrogels are chemically or physically crosslinked polymer systems that
form three-dimensional networks with high water absorption capacity.
Carboxymethylcellulose (CMC) is one of the major soluble derivatives of cellulose
widely applied in the medical and pharmaceutical fields due to its biocompatibility,
nontoxicity, biodegradability and film forming ability.2 Polyvinyl Alcohol (PVA) is a
synthetic polymer with wide pharmaceutical and biomedical applications as it is nontoxic,
non-carcinogenic, bioadhesive and easy to process.3 In this work, we developed
a mucoadhesive hydrogel from a CMC and PVA polymer blend for chemotherapeutic
loading and suitable rheological properties for intravesical instillation, especially
designed for treating superficial BC with increased residence time of chemotherapeutic
agent. Three formulations (C1, C2 and C3) at different CMC concentrations were
prepared - 1%, 2% and 3% (w/v), respectively. PVA concentration corresponded to 1%
(w/v) for all formulations. The polymers were separately solubilized in Milli-Q water and
then mixed prior to the addition of 20% (v/v) glycerin to increase the
mucoadhesiveness of the material. The hydrogels were characterized according to
their organoleptic and rheological properties to evaluate the behavior of the material
under tension and temperature. Accelerated stability tests of the pharmaceutical form
were also performed. Comparatively, formulations with glycerin presented improved
mucoadhesiveness, and formulations with 1 and 2% of CMC presented more adequate
rheological behavior for the proposed application. In conclusions, the systems
presented adequate properties for the delivery of chemotherapeutic agents for
optimized BC treatments.
Como referenciar
LIMA, C.S.A.; VARCA, J.O.; FERRARI, A.; NOGUEIRA, K.M.; VARCA, G.H.C.; LUGAO, A.B. Development of mucoadhesive PVA/CMC based hydrogel for intravesical chemotherapy. In: CONGRESSO BRASILEIRO DE ENGENHARIA E CIÊNCIA DOS MATERIAIS, 23., 04-08 de novembro, 2018, Foz do Iguaçu, PR. Resumo... p. 7343-7343. Disponível em: http://repositorio.ipen.br/handle/123456789/29662. Acesso em: 03 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.