Development of theranostic nanomaterial: Synthesis and Characterization of novel fluorescent crystalline mesoporous β-Tricalcium Phosphate nanoparticles
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2018
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CONGRESSO DA SOCIEDADE LATINO AMERICANA DE BIOMATERIAIS, ORGÃOS ARTIFICIAIS E ENGENHARIA DE TECIDOS, 15.; CONGRESSO LATINO AMERICANO DE ÓRGÃOS ARTIFICIAIS E BIOMATERIAIS, 10.
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O Calcium phosphates, including hydroxyapatite [HA, Ca10 (PO4)6(OH)2] and beta-tricalcium phosphate [β-TCP, Ca3(PO4)2], are the main mineral component of bone tissue and teeth. The synthetic calcium phosphates are of special interest in medicine because of their biocompatibility, bioactivity and non-toxicity. β-TCP is advantageous to HA for drug delivery system due to their high solubility and controllable bioresorption rate. To obtain β-TCP, the literature reports the transformation of calcium deficient hydroxyapatite (CDHA) to β-TCP since it could not be synthesized directly in aqueous solution, until now. For the first time, fluorescent β-TCP have been successfully synthesized by wet precipitation method at room temperature with a Ca/P molar ratio equal to 1.5 and doped with europium ion. The present work is concerned with the preparation of β-TCP and it characterization through XRD, Fluorescence and TEM analysis. The results showed well-characterized peaks of crystalline pure β-TCP (JCPDS 09-0169) for the dried powder, with intense visible emission. The TEM micrographs exhibits mesoporous structure, which is suitable as a drug carrier.
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SILVA, F.R.O.; BRESSIANI, A.H.A.; LIMA, N.B. Development of theranostic nanomaterial: Synthesis and Characterization of novel fluorescent crystalline mesoporous β-Tricalcium Phosphate nanoparticles. In: BURITI, JOSUE da S. (ed.); CRUZ, RITA de C.A.L. (ed.); FOOK, MARCUS V.L. (ed.). In: CONGRESSO DA SOCIEDADE LATINO AMERICANA DE BIOMATERIAIS, ORGÃOS ARTIFICIAIS E ENGENHARIA DE TECIDOS, 15.; CONGRESSO LATINO AMERICANO DE ÓRGÃOS ARTIFICIAIS E BIOMATERIAIS, 10., 22 a 25 de agosto, 2018, João Pessoa, PB. Resumo... Belo Horizonte, MG: Sociedade Latino Americana de Biomateriais, Engenharia de Tecidos e Órgãos Artificiais, 2018. p. 244-244. Disponível em: http://repositorio.ipen.br/handle/123456789/29492. Acesso em: 30 Dec 2025.
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