Mucoadhesive polymers and their applications in drug delivery systems for the treatment of bladder cancer

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dc.contributor.authorLIMA, CAROLINE S.A. dept_BR
dc.contributor.authorVARCA, JUSTINE P.R.O.pt_BR
dc.contributor.authorALVES, VICTORIA M.pt_BR
dc.contributor.authorNOGUEIRA, KAMILA M.pt_BR
dc.contributor.authorCRUZ, CASSIA P.C.pt_BR
dc.contributor.authorRIAL-HERMIDA, M. ISABELpt_BR
dc.contributor.authorKADLUBOWSKI, SLAWOMIR S.pt_BR
dc.contributor.authorVARCA, GUSTAVO H.C.pt_BR
dc.contributor.authorLUGAO, ADEMAR B.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2022-12-08T19:29:27Z
dc.date.available2022-12-08T19:29:27Z
dc.date.issued2022pt_BR
dc.description.abstractBladder cancer (BC) is the tenth most common type of cancer worldwide, affecting up to four times more men than women. Depending on the stage of the tumor, different therapy protocols are applied. Non-muscle-invasive cancer englobes around 70% of the cases and is usually treated using the transurethral resection of bladder tumor (TURBIT) followed by the instillation of chemotherapy or immunotherapy. However, due to bladder anatomy and physiology, current intravesical therapies present limitations concerning permeation and time of residence. Furthermore, they require several frequent catheter insertions with a reduced interval between doses, which is highly demotivating for the patient. This scenario has encouraged several pieces of research focusing on the development of drug delivery systems (DDS) to improve drug time residence, permeation capacity, and target release. In this review, the current situation of BC is described concerning the disease and available treatments, followed by a report on the main DDS developed in the past few years, focusing on those based on mucoadhesive polymers as a strategy. A brief review of methods to evaluate mucoadhesion properties is also presented; lastly, different polymers suitable for this application are discussed.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDFAPESP: 17/50332-0; 19/01315-1; 21/09636-1pt_BR
dc.format.extent1-25pt_BR
dc.identifier.citationLIMA, CAROLINE S.A. de; VARCA, JUSTINE P.R.O.; ALVES, VICTORIA M.; NOGUEIRA, KAMILA M.; CRUZ, CASSIA P.C.; RIAL-HERMIDA, M. ISABEL; KADLUBOWSKI, SLAWOMIR S.; VARCA, GUSTAVO H.C.; LUGAO, ADEMAR B. Mucoadhesive polymers and their applications in drug delivery systems for the treatment of bladder cancer. <b>Gels</b>, v. 8, n. 9, p. 1-25, 2022. DOI: <a href="https://dx.doi.org/10.3390/gels8090587">10.3390/gels8090587</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/33418.
dc.identifier.doi10.3390/gels8090587pt_BR
dc.identifier.fasciculo9pt_BR
dc.identifier.issn2310-2861pt_BR
dc.identifier.orcid0000-0002-1737-3191pt_BR
dc.identifier.orcid0000-0002-6545-237Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.percentilfi79.7pt_BR
dc.identifier.percentilfiCiteScore32.25pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/33418
dc.identifier.vol8pt_BR
dc.relation.ispartofGelspt_BR
dc.rightsopenAccesspt_BR
dc.subjectadhesion
dc.subjectdrug delivery
dc.subjectbladder
dc.subjectneoplasms
dc.subjecthydrogels
dc.subjectpolymers
dc.subjecttherapy
dc.titleMucoadhesive polymers and their applications in drug delivery systems for the treatment of bladder cancerpt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorVICTORIA MARTINS ALVES
ipen.autorKAMILA MOREIRA NOGUEIRA
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorGUSTAVO HENRIQUE COSTAVARCA
ipen.autorCASSIA PRISCILA CUNHA DA CRUZ
ipen.autorJUSTINE PAULA RAMOS DE OLIVEIRA
ipen.autorCAROLINE SANTOS ALVES DE LIMA
ipen.codigoautor15538
ipen.codigoautor12758
ipen.codigoautor339
ipen.codigoautor8661
ipen.codigoautor15070
ipen.codigoautor8726
ipen.codigoautor14945
ipen.contributor.ipenauthorVICTORIA MARTINS ALVES
ipen.contributor.ipenauthorKAMILA MOREIRA NOGUEIRA
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorGUSTAVO HENRIQUE COSTAVARCA
ipen.contributor.ipenauthorCASSIA PRISCILA CUNHA DA CRUZ
ipen.contributor.ipenauthorJUSTINE PAULA RAMOS DE OLIVEIRA
ipen.contributor.ipenauthorCAROLINE SANTOS ALVES DE LIMA
ipen.date.recebimento22-12
ipen.identifier.fi4.6pt_BR
ipen.identifier.fiCiteScore2.9pt_BR
ipen.identifier.ipendoc29052pt_BR
ipen.identifier.iwosWoSpt_BR
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ipen.range.percentilfi75.00 - 100.00
ipen.type.genreArtigo
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sigepi.autor.atividadeLUGAO, ADEMAR B.:339:740:Npt_BR
sigepi.autor.atividadeVARCA, GUSTAVO H.C.:8661:740:Npt_BR
sigepi.autor.atividadeCRUZ, CASSIA P.C.:15070:750:Npt_BR
sigepi.autor.atividadeNOGUEIRA, KAMILA M.:12758:750:Npt_BR
sigepi.autor.atividadeALVES, VICTORIA M.:15538:750:Npt_BR
sigepi.autor.atividadeVARCA, JUSTINE P.R.O.:8726:750:Npt_BR
sigepi.autor.atividadeLIMA, CAROLINE S.A. de:14945:750:Spt_BR
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