Green nanotechnology of MGF‑AuNPs for immunomodulatory intervention in prostate cancer therapy
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Men with castration-resistant prostate cancer (CRPC) face poor prognosis and increased risk of treatment-incurred adverse effects resulting in one of the highest mortalities among patient population globally. Immune cells act as double-edged sword depending on the tumor microenvironment, which leads to increased infiltration of pro-tumor (M2) macrophages. Development of new immunomodulatory therapeutic agents capable of targeting the tumor microenvironment, and hence orchestrating the transformation of pro-tumor M2 macrophages to anti-tumor M1, would substantially improve treatment outcomes of CRPC patients. We report, herein, Mangiferin functionalized gold nanoparticulate agent (MGF-AuNPs) and its immunomodulatory characteristics in treating prostate cancer. We provide evidence of immunomodulatory intervention of MGF-AuNPs in prostate cancers through observations of enhanced levels of anti-tumor cytokines (IL-12 and TNF-α) with concomitant reductions in the levels of pro-tumor cytokines (IL-10 and IL-6). In the MGF-AuNPs treated groups, IL-12 was elevated to ten-fold while TNF-α was elevated to about 50-fold, while IL-10 and IL-6 were reduced by two-fold. Ability of MGF-AuNPs to target splenic macrophages is invoked via targeting of NF-kB signaling pathway. Finally, therapeutic efficacy of MGF-AuNPs, in treating prostate cancer in vivo in tumor bearing mice, is described taking into consideration various immunomodulatory interventions triggered by this green nanotechnology-based nanomedicine agent.
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KHOOBCHANDANI, MENKA; KHAN, ASLAM; KATTI, KAVITA K.; THIPE, VELAPHI C.; AL-YASIRI, AMAL Y.; MOHANDOSS, DARSHA K.D.; NICHOLL, MICHAEL B.; LUGAO, ADEMAR B.; HANS, CHETAN P.; KATTI, KATTESH V. Green nanotechnology of MGF‑AuNPs for immunomodulatory intervention in prostate cancer therapy. Scientific Reports, v. 11, n. 1, p. 1-30, 2021. DOI: 10.1038/s41598-021-96224-8. Disponível em: http://repositorio.ipen.br/handle/123456789/32394. Acesso em: 26 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.