Topical treatment of cutaneous leishmaniasis: wound reduction in mice using n-methyl glucamine from pvp and nano clay membranes
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Journal of Dermatology Research and Therapy
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Biomaterials comprise a scientific field where synthetic materials
are developed for pertinent biological functions, yielding a wide
diversity of new products. Although widely employed, they still
require improvement for therapeutic purposes. The objective of
this study was to develop poly (N-2-vinyl-pyrrolidone) (PVP), poly
(vinyl alcohol) (PVAl), clay, and N-methyl glucamine hydrogels for
the treatment of cutaneous leishmaniasis. The characterization
techniques used were tumescence, energy-dispersive X-ray
(EDX) spectroscopy. Clay and antimoniate were found to disperse
homogeneously in the polymeric matrix. Evaluation of cytotoxicity
showed negative result. The in vivo tests used 12 BALB/c infected
with 3 × 104 amastigotes/mL of L. (L.) amazonensis. All mice
(4/4) from group II presented reduction of diameter wounds after
submitted to PVP, PVAl, clay (1,5%), and N-methyl glucamine (2.3
mg) hydrogels, differently from group I PVP, PVAl, and N-methyl
glucamine (1 mg) and III (control). Classified as results of a clinical
cure, drug release was efficient and such a matrix is a potential
contributor to an alternative human therapy capable of increasing
the quality of life of a patient who cannot use medication in the
conventional way because of side effects.
Como referenciar
OLIVEIRA, MARIA J.A. de; MAIA, REGINA; BRAZ, LUCIA A.; LUGAO, ADEMAR B.; AMATO, VALDIR S.; PARRA, DUCLERC F. Topical treatment of cutaneous leishmaniasis: wound reduction in mice using n-methyl glucamine from pvp and nano clay membranes. Journal of Dermatology Research and Therapy, v. 2, n. 5, p. 1-4, 2016. DOI: 10.23937/2469-5750/1510036. Disponível em: http://repositorio.ipen.br/handle/123456789/27174. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.