Anti‑SARS‑CoV‑2 equine F (Ab′)2 immunoglobulin as a possible therapy for COVID‑19
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The new outbreak of coronavirus disease 2019 (COVID-19) has infected and caused the death of
millions of people worldwide. Intensive efforts are underway around the world to establish effective
treatments. Immunoglobulin from immunized animals or plasma from convalescent patients
might constitute a specific treatment to guarantee the neutralization of the virus in the early
stages of infection, especially in patients with risk factors and a high probability of progressing
to severe disease. Worldwide, a few clinical trials using anti-SARS-CoV-2 immunoglobulins from
horses immunized with the entire spike protein or fragments of it in the treatment of patients with
COVID-19 are underway. Here, we describe the development of an anti-SARS-CoV-2 equine F(ab′)2
immunoglobulin using a newly developed SARS-CoV-2 viral antigen that was purified and inactivated
by radiation. Cell-based and preclinical assays showed that the F(ab′)2 immunoglobulin successfully
neutralizes the virus, is safe in animal models, and reduces the severity of the disease in a hamster
model of SARS-CoV-2 infection and disease.
Como referenciar
BOTOSSO, VIVIANE F.; JORGE, SORAIA A.C.; ASTRAY, RENATO M.; GUIMARAES, ANA M. de S.; MATHOR, MONICA B.; CARNEIRO, PATRICIA dos S. de; DURIGON, EDISON L.; COVAS, DIMAS; OLIVEIRA, DANIELLE B.L. de; OLIVEIRA, RICARDO das N.; MARIA, DURVANEI A.; ETO, SILAS F.; GALLINA, NEUZA M.F.; PIDDE, GISELLE; SQUAIELLA‑BAPTISTAO, CARLA C.; SILVA, DILZA T.; VILLAS‑BOAS, ISADORA M.; FERNANDES, DAYANNE C.; AUADA, ALINE V.V.; BANARI, ALEXANDRE C.; SOUZA FILHO, ANTONIO F. de; BIANCONI, CAMILA; UTESCHER, CARLA L. de A.; OLIVEIRA, DENISE C.A.; MARIANO, DOUGLAS O.C.; BARBOSA, FLAVIA F.; RONDON, GIULIANA; KAPRONEZAI, JOSANA; SILVA, JULIANA G. da; GOLDFEDER, MAURICIO B.; COMONE, PRISCILA; CASTILHO JUNIOR, REGIS E.; PEREIRA, TAIANA T.S.; WEN, FAN H.; TAMBOURGI, DENISE V.; CHUDZINSKI‑TAVASSI, ANA M. Anti‑SARS‑CoV‑2 equine F (Ab′)2 immunoglobulin as a possible therapy for COVID‑19. Scientific Reports, v. 12, p. 1-17, 2022. DOI: 10.1038/s41598-022-07793-1. Disponível em: http://repositorio.ipen.br/handle/123456789/33213. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.