Radiolabeled NGR phage display peptide sequence for tumor targeting
Carregando...
Data
Data de publicação
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
Applied Radiation and Isotopes
ODS
Exportar
Resumo
The asparagine-glycine-arginine (NGR) peptide sequence found by phage display, was radiolabeled with technetium-99m and tested in different tumor models. Similar uptake occurred with ovarian and lung tumor cells. Biodistribution of the radiotracer revealed predominant renal excretion with more substantial uptake in animals bearing ovarian tumor cells. In contrast imaging studies indicated better visualization for lung tumor. NGR peptide was characterized as a promising diagnostic candidate, particularly for lung cancer. Improvements are envisaged using NGR combined with RGD as a heterodimer molecule.
Como referenciar
FAINTUCH, B.L.; OLIVEIRA, E.A.; TARGINO, R.C.; MORO, A.M. Radiolabeled NGR phage display peptide sequence for tumor targeting. Applied Radiation and Isotopes, v. 86, p. 41-45, 2014. DOI: 10.1016/j.apradiso.2013.12.035. Disponível em: http://repositorio.ipen.br/handle/123456789/27703. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.