Ionizing radiation synthesis of hydrogel nanoparticles of gelatin and polyethylene glycol at high temperature
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Polymers
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Nanohydrogel particles of polyethylene glycol (PEG), gelatin (GEL), and PEG–GEL mixtures (MIXs) were synthesized with a high electron beam and 60Co gamma-ray radiation. The
relatively novel technique of Asymmetrical Flow Field Flow Fractionation (AF4 or AFFFF) coupled
to a Multi-Angle Laser Light Scattering (MALLS) detector was mainly used to determine the hydrodynamic diameter (Dh) of the radiation-synthesized PEG, GEL, and PEG–GEL nanohydrogel
particles. Our approach to achieving nanohydrogel particles is to enhance the intracrosslinking
reactions and decrease the intercrosslinking reactions of the C-centered radicals of the PEG and GEL.
The intracrosslinking reactions of these free radicals were enhanced via irradiation at temperatures of
77–80 ◦C and using a high dose rate and pulsed irradiation. The shorter average distance between
the C-centered free radicals on the backbone of the thermally collapsed PEG and GEL chain, due to
the destruction of hydrogen bonds, enhances the intracrosslinking reactions. It was observed that
increasing the dose and dose rate decreased the Dh. DLS results lined up with AF4 measurements.
This study provides researchers with a clean method to produce GEL–PEG hydrogels without the use
of toxic reagents. Particle size can be tuned with dose, dose rate, and temperature as demonstrated in
this work. This is ideal for medical applications as the use of ionizing radiation eliminates toxicity
concerns and provides simultaneous sterilization of the material.
Como referenciar
TAKINAMI, PATRICIA Y. I.; MASTRO, NELIDA L. del; ASHFAQ, AIYSHA; AL-SHEIKHLY, MOHAMAD. Ionizing radiation synthesis of hydrogel nanoparticles of gelatin and polyethylene glycol at high temperature. Polymers, v. 15, n. 20, p. 1-11, 2023. DOI: 10.3390/polym15204128. Disponível em: http://repositorio.ipen.br/handle/123456789/34346. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.