Assessment of pure-phase β – tricalcium phosphate (β – TCP) cylindrical ceramic implant osseointegration used in critical segmental bone defects of the radius of rabbits
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2023
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LATIN-AMERICAN CONGRESS OF ARTIFICIAL ORGANS AND BIOMATERIALS, 12th
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Introduction and objective
Although grafts show excellent skeletal incorporation, host’s morbidity and graft acquisition and quantity
limit their use. Alternatively, synthetic materials play an important role in reconstructive orthopaedic
surgery. To assess the occurrence of osseointegration using a customized β-TCP implant.
Methodology
Eighteen adult New Zealand rabbits were divided into 3 groups (n=6 per group). A defect was created in the
mid-diaphysis of each left radius with a high-speed drill. In Group-A and Group-B, β-TCP and allogenous
cortical bone grafts respectively were placed intro the radical defect, while the defect remained empty in
Group-C. Pain, swelling, limb alignment, lameness, foreign body reactions, osseo integration and implant
resorption were assessed through cãnical examination and qualitative radiographic, analysis immediately
postoperatively and 30, 60, 90 and 120 days postoperatively. All animals were euthanized on day 120, and
μCT and histological assessments for calcified and uncalcified specimens were performed.
Results and discussion
No clinical alterations were observed in any rabbit after 120 days. On radiographic and μCT images, as well
as upon histologic assessment, complete bone healing was observed in all rabbits in Group-B. Non-unions
were observed in all rabbits in Group-A and Group-C. Implant resorption was not observed in Group-A. This
study showed that β-TCP did not elicit any osteoconductivity and osseointegration. The lack of ceramic
bioactivity and resorption observed with β-TCP was probably due to low implant porosity and/or other
implant shape features. However, expected biocompatibility was present. Our hypothesis was that by
reducing porosity and gainingrigidity, we could have an alternative to maintain a good mechanical
characteristic, without forcing and breaking the implant and at the same time, allowing blood vessels, cells
and growth factors permeate the poresof the implant and form new bone throughout. But this feature was
not enough to promote the conduction of bone cells nor the integration between them in our implant.
Certainly, the porosity that we gained from the sintering process was too low to allow osseoconduction,
which differed from the works of other authors.
Conclusions
The customized β-TCP implant did not show such osseoconductive and osseointegrative characteristics
mentioned by other authors and they were not effective for the consolidation and integration between the
hosts bones and biomaterials. Further studies must be carried out to provide more information to classify
it as a proper material for use in the routine of orthopaedic reconstructive surgery in veterinary medicine.
Como referenciar
GARCIA, D.C.; MINGRONE, L.E.; PINOTTI. F.E.; SEADE, L.; MELO, R.; LUGAO, A.B.; SA, M.J.C. Assessment of pure-phase β – tricalcium phosphate (β – TCP) cylindrical ceramic implant osseointegration used in critical segmental bone defects of the radius of rabbits. In: LATIN-AMERICAN CONGRESS OF ARTIFICIAL ORGANS AND BIOMATERIALS, 12th, December 12-15, 2023, Mar del Plata, Argentina. Abstract... p. 107-107. Disponível em: https://repositorio.ipen.br/handle/123456789/47942. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.