Effect of nutritional stress and serum starvation on the optical absorbance of normal and malignant epithelial cell lines
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DANIELA SILVA
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Photobiomodulation has the potential to modulate cellular responses in various pathological conditions by affecting different
signaling pathways. This study aimed to investigate the optical absorbance spectra of normal, dysplastic, and malignant
epithelial cell lines under normal and nutritional stress conditions. HaCAT (keratinocyte), DOK (oral dysplastic), and oral
squamous cell carcinoma (OSCC) cell lines (CA1, Luc4, SCC9) were evaluated regarding their optical absorbance after culture
with 0-10% fetal bovine serum. Absorbance measurements indicated that HaCAT under serum starvation exhibited higher
absorbance at blue (430nm) and near-infrared (906nm) wavelengths. DOK showed absorption at 440 nm and 945 nm. OSCC
cells showed absorption peaks at blue (400-428nm) and near-infrared. These findings highlight the importance of tailoring PBM
parameters to individual needs to achieve optimal absorption and effectiveness. Moreover, the higher absorption peaks in the
blue region support further studies to elucidate the potential use of blue light in oral dysplastic lesions and OSCC.