Inhomogeneity in optical properties of rat brain: a study for LLLT dosimetry
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2013
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MECHANISMS FOR LOW-LIGHT THERAPY, 8th
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Over the last few years, low-level light therapy (LLLT) has shown an incredible suitability for a wide
range of applications for central nervous system (CNS) related diseases. In this therapeutic modality light
dosimetry is extremely critical so the study of light propagation through the CNS organs is of great
importance. To better understand how light intensity is delivered to the most relevant neural sites we
evaluated optical transmission through slices of rat brain point by point. We experimented red
(λ = 660 nm) and near infrared (λ = 808 nm) diode laser light analyzing the light penetration and
distribution in the whole brain. A fresh Wistar rat (Rattus novergicus) brain was cut in sagittal slices and
illuminated with a broad light beam. A high-resolution digital camera was employed to acquire data of
transmitted light. Spatial profiles of the light transmitted through the sample were obtained from the
images. Peaks and valleys in the profiles show sites where light was less or more attenuated. The peak
intensities provide information about total attenuation and the peak widths are correlated to the scattering
coefficient at that individual portion of the sample. The outcomes of this study provide remarkable
information for LLLT dose-dependent studies involving CNS and highlight the importance of LLLT
dosimetry in CNS organs for large range of applications in animal and human diseases.
Como referenciar
SOUSA, MARCELO V.P.; PRATES, RENATO; KATO, ILKA T.; SABINO, CAETANO P.; YOSHIMURA, TANIA M.; SUZUKI, LUIS C.; MAGALHAES, ANA C.; YOSHIMURA, ELISABETH M.; RIBEIRO, MARTHA S. Inhomogeneity in optical properties of rat brain: a study for LLLT dosimetry. In: HAMBLIN, MICHAEL R. (ed.); ARANY, PRAVEEN R. (ed.); CARROLL, JAMES D. (ed.). In: MECHANISMS FOR LOW-LIGHT THERAPY, 8th, February 02, 2013, San Francisco, CA, USA. Proceedings... Bellingham, WA, USA: International Society for Optics and Photonics, 2013. p. 856905-1 - 856905-6. (SPIE Proceedings Series, 8569). DOI: 10.1117/12.2002836. Disponível em: http://repositorio.ipen.br/handle/123456789/27652. Acesso em: 26 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.