JOSE DE SOUZA CALDEIRA FILHO
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Capítulo IPEN-doc 13639 Development of somatostatin based radiopharmaceuticals for receptor mediated radionuclide therapy2007 - ARAUJO, E.B.; CALDEIRA FILHO, J.S.; NAGAMATI, L.T.; MURAMOTO, E.; COLTURATO, M.T.; COUTO, R.; OKASAKI, K.; SUZUKI, M.F.; GUIMARAES, M.I.C.C.The paper describes the methodology used for and the results of labelling [Tyr3 ]octreotate (TATE) with radioiodine (131I) and [DOTA,Tyr3 ]octreotate (DOTATATE) with 131I and lutetium (177Lu). The quality control and purification procedures are also described. Biodistribution studies were performed in normal Swiss mice and in nude mice bearing AR42J tumours. In vitro studies were used to evaluate the affinity of the radiopharmaceuticals for somatostatin receptors in rat brain cortex and tumour cells. Saturation binding and the internalization of the labelled peptides were determined. The frequency of micronuclei in peripheral blood lymphocytes exposed to different radioactive concentrations of [131I]DOTATATE and [ 177Lu]DOTATATE was evaluated by micronucleus assay.Artigo IPEN-doc 13234 Comparison of sup(131)I-TYRsup(3)-octreotate and sup(131)I-DOTA-TYRsup(3)Octreotate: the egffect of DOTA on pharmacokinetics and stability2005 - ARAUJO, E.B. de; MURAMOTO, E.; NAGAMATI, L.T.; CALDEIRA FILHO, J.S.; COUTO, R.M.; SILVA, C.P.G.Artigo IPEN-doc 09760 Direct labeling of chemotactic peptide ForNleLFNleYK radioiodine-in vivo- stability evaluation2003 - LAVINAS, T.; MURAMOTO, E.; CALDEIRA FILHO, J.S.; SAMPEL, C.J.C; SILVA, C.P.G.; ARAUJO, E.B.Some peptides are naturally occuring inflammatory mediators which specifically bind to receptors abundantly present in the area of inflammation, and owing to their small size, they rapidly clear from all nontarget tissues. ForNleLFNleYK is a synthetic chemotactic peptide with high affinity to receptors on the white blood cell membranes. This hexapeptide contains a tyrosine residue susceptible to iodination by oxidative eletrophilic substitution direct labeling. The aim of this study was the radioiodination of ForNleLFNleYK using the direct method (chloramine T) and its in vivo stability evaluation. The labeled compound was obtained in a short reaction time with high radiochemical purity (96.8 ± 0.84%) and remained stable over 48 hours when stored at low temperature. Biological distribution studies showed an uptake in inflammated tight significantly greater than the normal tight (p < 0.05, Student t test), and some in vivo dehalogenation of the compound.Artigo IPEN-doc 11424 Labeling of DOTA-Tyrsup(3)-octreotate with sup(177)Lu - stabillity and biodistribution study2005 - CALDEIRA FILHO, JOSE S.; MURAMOTO, EMIKO; SILVA, CONSTANCIA P.G.; ARAUJO, ELAINE B.