Direct labeling of chemotactic peptide ForNleLFNleYK radioiodine-in vivo- stability evaluation
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ALASBIMN Journal
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Some peptides are naturally occuring inflammatory mediators which
specifically bind to receptors abundantly present in the area of inflammation,
and owing to their small size, they rapidly clear from all nontarget tissues.
ForNleLFNleYK is a synthetic chemotactic peptide with high affinity to
receptors on the white blood cell membranes. This hexapeptide contains a
tyrosine residue susceptible to iodination by oxidative eletrophilic
substitution direct labeling. The aim of this study was the radioiodination of
ForNleLFNleYK using the direct method (chloramine T) and its in vivo
stability evaluation. The labeled compound was obtained in a short reaction
time with high radiochemical purity (96.8 ± 0.84%) and remained stable over
48 hours when stored at low temperature. Biological distribution studies
showed an uptake in inflammated tight significantly greater than the normal
tight (p < 0.05, Student t test), and some in vivo dehalogenation of the
compound.
Como referenciar
LAVINAS, T.; MURAMOTO, E.; CALDEIRA FILHO, J.S.; SAMPEL, C.J.C; SILVA, C.P.G.; ARAUJO, E.B. Direct labeling of chemotactic peptide ForNleLFNleYK radioiodine-in vivo- stability evaluation. ALASBIMN Journal, v. ano 6, n. 22, 2003. Disponível em: http://repositorio.ipen.br/handle/123456789/7489. Acesso em: 27 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.