ANGELICA BUENO BARBEZAN

ANGELICA BUENO BARBEZAN

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Synthesis and characterization of Au-198 nanoparticles for radiotherapy
2024 - RIGO, M.; BARBEZAN, A.; TALACIMON, C.; TEODORO, L.; RODRIGUES, P.; ROSERO, W.; NOGUEIRA, T.; ROSTELATO, M.
In vivo distribution dynamics of gold nanoparticles
2024 - BARBEZAN, A.B.; ROSERO, W.A.W.; ALMEIDA, L.F.; RIGO, M.E.Z.; SILVA, F.F.A.; ROSTELATO, M.E.C.M.
Radioactive gold nanoparticles coated with BSA
2024 - BARBEZAN, ANGELICA B.; ROSERO, WILMMER A.A.; VIEIRA, DANIEL P.; RIGO, MARIA E.Z.; SILVA, GIOVANA D. da; RODRIGUES, ALEX A.; ALMEIDA, LUIS F. de; SILVA, FABIO F.A. da; RIVERA, ANDY G.; SILVA, NATANAEL G. da; BERNARDES, EMERSON S.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.
Background: Nanotechnology has revolutionized medicine, especially in oncological treatments. Gold nanoparticles (AuNPs) stand out as an innovative alternative due to their biocompatibility, potential for surface modification, and effectiveness in radiotherapeutic techniques. Given that prostate cancer ranks as one of the leading malignancies among men, there's a pressing need to investigate new therapeutic approaches. Methods: AuNPs coated with bovine serum albumin (BSA) were synthesized and their cytotoxicity was assessed against prostate tumor cell lines (LNCaP and PC-3), healthy prostate cells (RWPE-1), and endothelial control cells (HUVEC) using the MTS/PMS assay. For in vivo studies, BALB/C Nude mice were employed to gauge the therapeutic efficacy, biodistribution, and hematological implications post-treatment with BSA-coated AuNPs. Results: The BSA-coated AuNPs exhibited cytotoxic potential against PC-3 and LNCaP lines, while interactions with RWPE-1 and HUVEC remain subjects for further scrutiny. Within animal models, a diverse therapeutic response was observed, with certain instances indicating complete tumor regression. Biodistribution data emphasized the nanoparticles' affinity towards particular organs, and the majority of hematological indicators aligned with normative standards. Conclusions: BSA-coated AuNPs manifest substantial promise as therapeutic tools in treating prostate cancer. The present research not only accentuates the nanoparticles' efficacy but also stresses the imperative of optimization to ascertain both selectivity and safety. Such findings illuminate a promising trajectory for avant-garde therapeutic modalities, holding substantial implications for public health advancements.
Development of radioactive nanoparticles functionalized with gum arabic to be used in nanobrachytherapy
2023 - ROSERO, WILMMER A.A.; BARBEZAN, ANGELICA B.; RIGO, MARIA E.Z.; RODRIGUES, PRISCILA S.; TEODORO, LARA E.H.; TALACIMON, CRISTHIAN F.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.
The development of new materials emerges as an alternative to the treatment of cancer, from the combination of nanotechnology and brachytherapy a new area of research was born, Nanobrachytherapy, which through the properties of nanometric materials can achieve better results in the fight against cancer. The objective of this work is classified as radiotherapy, which consists of the use of ionizing radiation to destroy or inhibit the growth of abnormal cells that form a tumor. [1] The ability to integrate NPsAu into biological systems is due to the nanometric dimensions of NPsAu probes which facilitate their incorporation into biological systems, as well as their bioconjugation and non-cytotoxic potential. [2] Taking into account the previous objective, gold was selected as the base element for obtaining nanometric systems, which due to its chemical richness and especially due to the intrinsic properties of one of its radioisotopes, which would allow us in theory to meet the stated objective. . Initially, it was based on the knowledge of the literature, and non-radioactive nanometric systems were obtained, and after a series of stability, characterization and application tests, the radioactive nanometric systems were obtained. Working with radioactive systems posed a great challenge, and up to now it presents us with situations to solve, but we have managed to create a methodology for obtaining, characterizing and applying radioactive gold nanoparticles, and also obtaining positive results from their application.
Characterization of FXG dosimeters with gold nanoparticles for brachytherapy applications
2023 - RODRIGUES, PRISCILA; BURIN, ANA; BARBEZAN, ANGELICA; TALACIMON, CRISTHIAN; ILCA, MEDEIROS; TEODORO, LARA E.H.; RIGO, MARIA; GESSERAME, MAYSA; TAVARES, PAULO; NOGUEIRA, THUANY; ROSERO, WILMMER; RODRIGUES JUNIOR, ORLANDO; ZEITUNI, CARLOS; ROSTELATO, MARIA