LUCAS VERDI ANGELOCCI

LUCAS VERDI ANGELOCCI

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Study of a new formulation for a phosphorus-32 polymeric source for use in brachytherapy
2024 - TEODORO, L.E.H.; TALACIMON, C.F.; SILVA, A.C.K.D.S.; BURIN, A.L.; MEDEIROS, I.M.M.A.; RIGO, M.E.Z.; RODRIGUES, P.S.; TAVARES, P.V.D.S.; SGRIGNOLI, S.S.; ANGELOCCI, L.V.; VIEIRA, J.M.; ZEITUNI, C.A.; ROSTELATO, M.E.C.M.
Purpose: To evaluate a new material for a phosphorus-32 polymeric film to use in brachytherapy for paraspinal and intracranial tumors and to analyze its activity distribution. Methods: As phosphorus-32 comes in the form of orthophosphoric acid, several tests were conducted to determine the best resin to encapsulate it. Initially, acid without radiation was used. Each test was repeated at least five times to ensure its result. Two variables were checked to evaluate the results: whether the resin cured or not, and if the final product was flexible. All tests were conducted with the selected resin being poured in molds of 5.0 x 5.0 x 0.04 cm. After selecting the considered suitable resins, acid with the active phosphorus-32 was used to produce the source. The film’s activity was measured on an ionization chamber detector. After measuring the activity from the whole film, it was cut into pieces of 1.0 x 1.0 cm and then measured again to verify the activity’s distribution. Results: From the resin tests, two of them stood out, for both their curing properties and malleability: silicone rubber with platinum catalyst and polyvinyl alcohol (PVA). Other resins evaluated whether did not cure or the film was considered not flexible. The activity measurements for the silicone rubber samples had a mean value of 227.92 ± 1.30 MBq (or 6.160 ± 0.005 mCi) and the distribution was acceptable. For the PVA, the activity mean value was 243.09 ± 1.39 MBq (or 6,573 ± 0.005 mCi) and the distribution was also acceptable. Conclusion: This work indicates a potential for a new flexible brachytherapy source, which could improve the surgical technique for central nervous system tumor resection and treatment. The activity results were promising according to the literature for a HDR source and further investigation on its dosimetry is needed to evaluate it.
Characterization of the anisotropy function of a new 125I brachytherapy source using thermoluminescent dosimetry
2024 - NOGUEIRA, THUANY C.; ANGELOCCI, LUCAS V.; SANTOS, HAMONA N. dos; TALACIMON, CRISTHIAN F.; TEODORO, LARA E.H.; RIGO, MARIA E.Z.; RODRIGUES, PRISCILA S.; BURIN, ANA L.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.
Thermoluminescent dosimetry planning through MNCP
2023 - NOGUEIRA, THUANY; TALACIMON, CRISTHIAN; TEODORO, LARA; RIGO, MARIA; RODRIGUES, PRISCILA; ANGELOCCI, LUCAS; NOVAES, HAMONA; ZEITUNI, CARLOS; ROSTELATO, MARIA
Dosimetric approach of Au-198 nanoparticles with radiochromic film
2023 - RIGO, MARIA; ANGELOCCI, LUCAS; RODRIGUES, PRISCILA; TALACIMON, CRISTHIAN; MEDEIROS, ILCA; TEODORO, LARA; NOGUEIRA, THUANY; ROSERO, WILMMER; ZEITUNI, CARLOS; ROSTELATO, MARIA
Development of a new material to encapsulate phosphorus-32 for use in brachytherapy
2022 - TEODORO, LARA E.H.; TALACIMON, CRISTHIAN F.; ROSERO, WILMMER A.A.; RIGO, MARIA E.Z.; RODRIGUES, PRISCILA S.; NOGUEIRA, THUANY C.; ANGELOCCI, LUCAS V.; ROSTELATO, MARIA E.C.M.
The term cancer refers to a set of malignant diseases that have in common the disordered growth of mutated cells, which can invade adjacent tissues or distant organs[1]. In 2020, cancer of the central nervous system (CNS) represented 1.6% of all new malignant tumor cases in the world, and about 2.5% of all new cancer deaths[2]. A promising radioactive source for use in intracavitary brachytherapy is phosphorus-32. This source has been prominent as a minimally invasive treatment for craniopharyngiomas and in the treatment of metastatic bone diseases in general[3]. To encapsulate phosphorus-32 and make it a viable radioactive source for use in medicine, some methods have emerged. In this work, we are developing a fabric soaked in industrial latex for this purpose, as this source comes in the form of orthophosphoric acid in aqueous solution and as industrial latex is soluble in water. Tests carried out so far show that the material supports orthophosphoric acid while is still malleable, which is essential for treating spinal cancer.