LUCAS VERDI ANGELOCCI
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Artigo IPEN-doc 31162 A dosimetric evaluation using the Monte Carlo method considering geometric variations of the iodine-125 seed for brachytherapy2024 - CHICO, H.S.; ANGELOCCI, L.V.; ZEITUNI, C.A.; SOUZA, C.D.; SGRIGNOLI, S.S.; ROSTELATO, M.E.C.M.The Institute for Energy and Nuclear Research – IPEN-CNEN/SP is uniquely positioned to develop a new source of Iodine-125 for brachytherapy treatment. Therefore, research into the dosimetric process and source design is widely studied. Task Group 43 – TG 43 cites methodologies for dosimetry of sources for brachytherapy, the most used method is Monte Carlo. However, the dosimetric protocol does not mention possible variations in the source geometry after its conception. The investigative focus of the work was to obtain measurements of the Iodine-125 seed during the production stages until completion, quantify them and simulate them using the Monte Carlo method with the MCNP – 4C code, the formalism was in water and a 101x101 matrix was used to calculate the dose point by point. Two variations were chosen: a) seed length; b) nucleus length, using a batch of 100 seeds for each case. 100 simulations were carried out for each variation and one simulation using the reference seed geometry. The following calculations were applied: relative difference to compare variations to the reference; average among the 100 seeds of each batch to calculate the standard deviation. In both cases there was no point that exceeded 4.48% relative difference, and for standard deviation the largest point was 1.6%, while the Type A uncertainty was 0.018% at the largest point.Artigo IPEN-doc 30558 Estimation of dose deposition by 198-AuNPs in the prostate with MCNP in simplified geometry2024 - SGRIGNOLI, S.S.; ANGELOCCI, L.V.; CHICO, H.S.; SOUZA, C.D.; BURIN, A.L.; RODRIGUES, P.S.; TEODORO, L.E.H.; MEDEIROS, I.M.M.; ZEITUNI, C.A.; ROSTELATO, M.E.C.M.Resumo IPEN-doc 29201 Development of a new material to encapsulate phosphorus-32 for use in brachytherapy2022 - TEODORO, LARA E.H.; TALACIMON, CRISTHIAN F.; ROSERO, WILMMER A.A.; RIGO, MARIA E.Z.; RODRIGUES, PRISCILA S.; NOGUEIRA, THUANY C.; ANGELOCCI, LUCAS V.; ROSTELATO, MARIA E.C.M.The term cancer refers to a set of malignant diseases that have in common the disordered growth of mutated cells, which can invade adjacent tissues or distant organs[1]. In 2020, cancer of the central nervous system (CNS) represented 1.6% of all new malignant tumor cases in the world, and about 2.5% of all new cancer deaths[2]. A promising radioactive source for use in intracavitary brachytherapy is phosphorus-32. This source has been prominent as a minimally invasive treatment for craniopharyngiomas and in the treatment of metastatic bone diseases in general[3]. To encapsulate phosphorus-32 and make it a viable radioactive source for use in medicine, some methods have emerged. In this work, we are developing a fabric soaked in industrial latex for this purpose, as this source comes in the form of orthophosphoric acid in aqueous solution and as industrial latex is soluble in water. Tests carried out so far show that the material supports orthophosphoric acid while is still malleable, which is essential for treating spinal cancer.Artigo IPEN-doc 27887 Dose-rate constant and air-kerma strength evaluation of a new 125I brachytherapy source using Monte-Carlo2021 - PRIMO, C.O.; ANGELOCCI, L.V.; KARAM JUNIOR, D.; ZEITUNI, C.A.; ROSTELATO, M.E.C.M.Brachytherapy is a modality of radiotherapy which treats tumors using ionizing radiation with sources located close to the tumor. The sources can be produced from several radionuclides in various formats, such as Iodine-125 seeds and Iridium-192 wires. In order to produce a new Iodine-125 seed in IPEN/CNEN and ensure its quality, it is essential to describe the seed dosimetry, so when applied in a treatment the lowest possible dose to neighboring healthy tissues can be reached. The report by the AAPM’s Task Group 43 U1 is a document that indicates the dosimetry procedures in brachytherapy based on physical and geometrical parameters. In this study, dose-rate constant and air-kerma strength parameters were simulated using the Monte Carlo radiation transport code MCNP4C. The air-kerma strength is obtained from an ideal modeled seed, since its actual value should be measured for seeds individually in a specialized lab with a Wide-Angle Free-Air Chamber (WAFAC). Dose-rate constant and air-kerma strength are parameters that depends on intrinsic characteristics of the source, i.e. geometry, radionuclide, encapsulation, and together they define the dose-rate to the reference point. Radial dose function describes the dose fall-off with distance from the source. This study presents the values found for these parameters with associated statistical uncertainty, and is part of a larger project that aims the full dosimetry of this new seed model, including experimental measures.