CARLA DARUICH DE SOUZA

CARLA DARUICH DE SOUZA

(Fonte: Lattes)

Resumo

Bsc in Medical Physics from UNESP in Botucatu Compleated at IPEN, University of São Paulo: 1) Master's Degree: Comparison between methods for fixing iodine-125 on silver substrate for fabricating sources used in Brachytherapy / 2) PhD: Parameters for production of iodine-125 sources used in brachytherapy and "sandwich" doctorate: Washington State University - training in radiochemistry and organic chemistry / 3) Post doctorate: Production of nanosources for the treatment of cancer / 4) Project: Analysis of methods to obtain / produce nuclear material for use in a radioisotope thermoelectric generator (RTG)/ Advisor of the Professional Master's Degree in Radiation Technology in Health / Professor of the Professional Master Program in the disciplines Dosimetry for Radiotherapy and Radiotherapy Fundamentals / Professor of the Academic Master Program in the discipline TNA5805 - Brachytherapy: Fundamentals, Production, Application, Dosimetry and Quality Research Associate of KAERI - Korean Atomic Energy and Research Institute (Text obtained from the Currículo Lattes on October 6th 2021)

Formada em Física Médica pela UNESP em Botucatu Realizado no IPEN-USP/ SP: 1) Mestrado: Comparação entre métodos de fixação do iodo-125 em substrato de prata para confecção de fontes utilizadas em Braquiterapia / 2) Doutorado: Parâmetros para produção de confecção de fontes de iodo-125 utilizadas em Braquiterapia e Doutorado sanduíche: Washington State University - treinamento em radioquímica / 3) Pós doutorado: Produção de nanofontes para tratamento de câncer / 4) Projeto: Análise de formas de obtenção/produção do material nuclear para utilização em um gerador termoelétrico radioisotópico (RTG)/ Orientadora do Mestrado Profissional de Tecnologia das Radiações na Saúde/ Professora do Mestrado Profissional nas disciplinas Dosimetria para Radioterapia e Fundamentos de Radioterapia/ Professora do Mestrado Acadêmico na disciplina TNA5805 - Braquiterapia: Fundamentos, Produção, Aplicação, Dosimetria e Qualidade Research Associate do KAERI - Korean Atomic Energy and Research Institute (Texto extraído do Currículo Lattes em 06 out. 2021)

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A rare case of pulmonary artery trunk aneurysm
2025 - FERREIRA, HORTENCIA de J.; BORGES, JULIANA A.F.; ANDRADE, NATALIA S.G.S. de; CASTRO, JOSE T. de; REIS, FABIANO; SOUZA, CARLA D. de
Background: Pulmonary artery trunk aneurysm (PATA) is a rare and complex vascular anomaly characterized by the abnormal dilation of the initial portion of the pulmonary artery, posing significant diagnostic and therapeutic challenges. Purpose: This clinical case report aims to describe the follow-up of a patient with PATA, emphasizing the role of imaging in diagnosis and monitoring, as well as discussing potential associations with other conditions. Research Design: The study is designed as a clinical case report, detailing the longitudinal follow-up of a single patient with PATA. Study Sample: The subject of this study is a 48-year-old female patient with a history of idiopathic hypertension who developed a PATA. Data Collection and/or Analysis: Since 2010, the patient underwent various imaging exams, including echocardiography, computed tomography, and catheter angiography, to detect and evaluate the aneurysm at different stages. Results: The imaging results indicated a progression of the aneurysm over time, underscoring the importance of imaging in the early identification and monitoring of PATA. The report also explores the possible association of PATA with conditions such as pulmonary hypertension, Behçet’s disease, and Hughes-Stovin syndrome, highlighting the diagnostic complexity. Conclusions: Imaging diagnosis is crucial for the detection, characterization, and monitoring of PATA, providing essential information for selecting appropriate treatment options and achieving a satisfactory prognosis. An individualized treatment approach, considering both medical and surgical options, is necessary based on the clinical characteristics of each patient.
Investigation for Monte Carlo simulation with geometric simplification of the GammaCell 220 irradiator with experimental measurements using Fricke xylenol gel (FXG)
2024 - RODRIGUES, P.S.; BURIN, A.L.; TALACIMON, C.F.; MEDEIROS, I.M.M.A.; PEREIRA, J.J.N.; TEODORO, L.E.H.; RIGO, M.E.Z.; GESSERAME, M.M.F.; TAVARES, P.V.S.; MARTINS, A.C.; SOUZA, C.D.; ZEITUNI, C.A.; RODRIGUES JUNIOR, O.; ROSTELATO, M.E.C.M.
Radiation therapy necessitates dosimetry using materials with densities similar to human tissue and at a lower cost. Comparisons with simulation methods will help validate new dosimeters and their measurements. To experimentally simulate radiation effects, an industrial irradiator like the GammaCell 220 can be utilized. This study aims to validate FXG dosimetry through Monte Carlo simulations using the MCNP and TOPAS codes, employing a simplified geometry model of the GammaCell 220 irradiator. The FXG dosimeter demonstrated linearity with an R2 of 0.99517. Monte Carlo simulations using both codes showed coherence, with MCNP exhibiting greater similarity to experimental results. The incorporation of simplified Monte Carlo modeling demonstrates the feasibility of obtaining satisfactory results for the GammaCell 220 irradiator geometry. Additionally, it validates the applicability of FXG dosimetry for future utilization in radiation therapy.
Study of dose calculation of beta-emitting source for palliative treatment of spinal cancer using MCNP6.2 code
2024 - BURIN, A.L.; KOKA, A.; TALACIMON, C.; MEDEIROS, I.; TEODORO, L.; RODRIGUES, P.; TAVARES, P.; SPIGAROLI, S.; DARUICH, C.; ROSTELATO, M.
Assessing shielding thickness in Am-241 nuclear battery
2024 - ANTUNES, P.C.G.; SOUZA, C.D. de; SHORTO, J.M.B.; BELCHIOR JUNIOR, A.; JUNQUEIRA, F.C.; ZEITUNI, C.A.; CABRAL, E.L.L.; RIBEIRO, M.A.M.
A dosimetric evaluation using the Monte Carlo method considering geometric variations of the iodine-125 seed for brachytherapy
2024 - CHICO, H.S.; ANGELOCCI, L.V.; ZEITUNI, C.A.; SOUZA, C.D.; SGRIGNOLI, S.S.; ROSTELATO, M.E.C.M.
Estimation of dose deposition by 198-AuNPs in the prostate with MCNP in simplified geometry
2024 - SGRIGNOLI, S.S.; ANGELOCCI, L.V.; CHICO, H.S.; SOUZA, C.D.; BURIN, A.L.; RODRIGUES, P.S.; TEODORO, L.E.H.; MEDEIROS, I.M.M.; ZEITUNI, C.A.; ROSTELATO, M.E.C.M.
Evaluation of the possible benefits of breast cancer screening in women aged 40 to 49 years in the Steel Valley region, Brazil
2024 - LIMA, CATIA C.A.; SOUZA, CARLA D. de
Background: This study investigates the effectiveness of mammographic screening for women aged 40 to 49 in Brazil's Steel Valley Region. Despite a Ministry of Health recommendation to start screenings at 50, 25% of breast cancer cases occur in the 40-49 age group. Methods: The retrospective analysis, spanning 2008-2019 at Marcio Cunha Hospital, compared two groups: cancer diagnosed via screening mammography (277) and diagnostic mammography (229). Results: Results showed delayed diagnoses for non-screened women, with 4.16 times higher mortality rate. Screening facilitated earlier detection of less malignant cancers (85.9% vs. 43.7%). Women diagnosed through screening were more likely to preserve their breasts (28.9% vs. 55.5% for Radical Breast Surgery and 71.1% vs. 28.9% for Breast-Sparing Surgery), and fewer axillary lymphadenectomies were performed. All statistical tests performed returned a p-value lower than 0.05 showing high statistical significance. Conclusion: The findings support extending screening mammography access to all women over 40 in the Steel Valley region and underscore the need for broader-scale research in other areas. Recommendations include enhancing public awareness and establishing a breast cancer surveillance service.
Review of advances in coating and functionalization of gold nanoparticles
2024 - ROSERO, WILMMER A.A.; BARBEZAN, ANGELICA B.; SOUZA, CARLA D. de; ROSTELATO, MARIA E.C.M.
Nanoparticles, especially gold nanoparticles (Au NPs) have gained increasing interest in biomedical applications. Used for disease prevention, diagnosis and therapies, its significant advantages in therapeutic efficacy and safety have been the main target of interest. Its application in immune system prevention, stability in physiological environments and cell membranes, low toxicity and optimal bioperformances are critical to the success of engineered nanomaterials. Its unique optical properties are great attractors. Recently, several physical and chemical methods for coating these NPs have been widely used. Biomolecules such as DNA, RNA, peptides, antibodies, proteins, carbohydrates and biopolymers, among others, have been widely used in coatings of Au NPs for various biomedical applications, thus increasing their biocompatibility while maintaining their biological functions. This review mainly presents a general and representative view of the different types of coatings and Au NP functionalization using various biomolecules, strategies and functionalization mechanisms.
Radioactive seed localization for nonpalpable breast lesions
2024 - FERREIRA, HORTENCIA H.J.; SOUZA, CARLA D. de; POZZO, LORENA; RIBEIRO, MARTHA S.; ROSTELATO, MARIA E.C.M.
Background: This study is a systematic review with meta-analysis comparing radioactive seed localization (RSL) versus radio-guided occult lesion localization (ROLL) and wire-guided localization (WGL) for patients with impalpable breast cancer undergoing breast-conserving surgery and evaluating efficacy, safety, and logistical outcomes. The protocol is registered in PROSPERO with the number CRD42022299726. Methods: A search was conducted in the Embase, Lilacs, Pubmed, Scielo, Web of Science, and clinicaltrials.gov databases, in addition to a manual search in the reference list of relevant articles, for randomized clinical trials and cohort studies. Studies selected were submitted to their own data extraction forms and risk of bias analysis according to the ROB 2 and ROBINS 1 tools. A meta-analysis was performed, considering the random effect model, calculating the relative risk or the mean difference for dichotomous or continuous data, respectively. The quality of the evidence generated was analyzed by outcome according to the GRADE tool. Overall, 46 articles met the inclusion criteria and were included in this systematic review; of these, 4 studies compared RSL and ROLL with a population of 1550 women, and 43 compared RSL and WGL with a population of 19,820 women. Results: The results showed that RSL is a superior method to WGL in terms of surgical efficiency in the impalpable breast lesions’ intraoperative localization, and it is at least equivalent to ROLL. Regarding security, RSL obtained results equivalent to the already established technique, the WGL. In addition to presenting promising results, RSL has been proven to be superior to WGL and ROLL technologies.
Nationalization of brachytherapy radioactive sources in Brazil and the importance of IAEA cooperation
2023 - ROSTELATO, MARIA E.C.M.; FEHER, ANSELMO; ZEITUNI, CARLOS A.; ROSERO, WILMMER A.A.; SOUZA, CARLA D. de; MOURA, JOÃO A.
Brazil has a cancer incidence of about 625,000 cases a year. It is a public health problem, demanding constant efforts to deliver for patients the most efficient treatment modalities, improving their life expectancy and quality. Brachytherapy is a type of Radiotherapy where the radioactive source is placed close to or inside the tumor. The main advantage of the technique is to deliver the maximum dose in the target, saving healthy tissues. In Brazil, Our group had the objective of producing sources nationally, diminishing treatment costs, enabling the treatment to more patients. Some of our projects are developed in collaboration with the International Atomic Energy Agency-IAEA by technical cooperation projects. The IAEA participation is very important to provide technological transfer through scientific visits, expert missions, and contacts with more advanced centers. The financial support is also important, allowing us to buy the necessary equipment to make these cancer treatment sources production feasible in Brazil. Our team has received training through fellowships. We received some experts and organized several workshops to propagate the Brachytherapy technique at national and Latin American level. For producing new sources, five major areas must be considered: 1) source production: nuclear activation and/or radiochemical reaction; 2) welding; 3) quality control: leakage tests; 4) dosimetry and metrology; 5) operational procedures; 6) validation studies. To perform all steps, a multidisciplinary team works together to overcome difficulties. Our major projects are: Iridium-192 pellets: In Brazil there are 150 afterloading machines with pellets that replacement every 4 months (about 450 Iridium-192 sources a year). Our new production line, with the support of IAEA, is in progress, with the hot-cell being installed in a brand-new facility. Iridium-192 wires: In production since 1997, also supported by IAEA. The wire is activated at IPEN’s IEA-R1 reactor for 30 hours with 5x1013 n/cm-2.s-1 neutron flux resulting in 7.1 GBq (192 mCi) maximum activity. Iridium-192 seed: New seed for ophthalmic cancer treatment. The core presented 90% activity homogeneity. We are making the experimental dosimetry and Monte Carlo simulation. Iodine-125 seeds: Largely used in low dose brachytherapy. I-125 binding yield achieved with our new reaction was 90%; Laser welding presented 70% efficiency. Approved in all leakage tests. Our Iodine-125 seeds laboratory production is 90% ready. Other ongoing projects: polymeric Phosphorus-32 source for spinal cancer treatment, Gold-198 nanoparticles for prostate, breast, and liver cancer treatment, Iodine-125 seed as markers for non-palpable cancers, and dosimetry calculations for all new sources. All the projects are advancing, despite national funding difficulties. Withing those, several mSc, Phd, and Post-doc are getting their degrees. We will continue to develop new products hoping to help the Brazilian population fight against cancer. The support of IAEA has proven to be of the utmost importance for these projects not only in direct funding, but in providing knowledge to our team, the possibility to share information with the scientific community, and to form the next generation of scientists.