BARBARA SZOT MARCZEWSKI

Projetos de Pesquisa
Unidades Organizacionais
Cargo

Filtros

2005 - 20073
Limpar filtros

Configurações

Tem arquivos: true × Assunto: radiopharmaceuticals ×

Resultados de Busca

Agora exibindo 1 - 3 de 3
  • Imagem de Miniatura
    Artigo IPEN-doc 12030
  • Imagem de Miniatura
    Artigo IPEN-doc 11181
    Liquid kit for preparation of sup(188) rhenium-etidronate
    2005 - MARCZEWSKI, B.; DIAS, C.R.; MORAES, V.; OSSO JUNIOR, J.A.
    The aim of this study was the preparation of a liquid kit for radiolabeling of 188Re-HEDP (hydroxyethylidene diphosphonate). 188Re was obtained from alumina based 188W/ 188Re generators. This paper reports the efficacy of a cold kit stored for more than two weeks, determined by the dependence of the radiolabeling yields of 188Re-HEDP on the incubation time, reducing agent concentration, the effects of concentration of ligand, the pH of the reaction and the temperature. The cold kits showed a good stability when carrie-free rhenium-188 was added in the reaction mixture.
  • Imagem de Miniatura
    Artigo IPEN-doc 11183
    Tc-sup(99m) direct radiolabeling of monoclonal antibody I or egf/r3: quality control and image studies in mice
    2005 - DIAS, C.R.; MARCZEWSKI, B.; MORAES, V.; BARBOZA, M.F.; OSSO JUNIOR, J.A.
    Monoclonal antibodies (Mabs) have been useful for immunoscintigraphic applications in clinical diagnosis since they were introduced in the practice of nuclear medicine. The ior egf/r3 (Centis, Cuba) is a murine monoclonal antibody against epidermal growth factor receptor (EGF-R) and has been widely used in the radioimmunodiagnosis of tumors of epithelial origin. Labeled with 99mTc, its main application in Nuclear Medicine is the follow up, detection and evaluation of tumor recurrences. The objective of this work is to describe the preparation of a lyophilized formulation (kit) for radiolabeling the Mab ior egf/r3 with 99mTc for immunoscintigraphic applications. Radiolabeling efficiency, effects on immunoreactivity, image studies and stability of the formulation are reported. The study demonstrated that the kit formulation can be labeled with 99mTc at high yields and can be used to visualize in vivo human tumors of epithelial origin by immunoscintigraphy studies.