Tc-sup(99m) direct radiolabeling of monoclonal antibody I or egf/r3: quality control and image studies in mice
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2005
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Brazilian Archives of Biology and Technology
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Resumo
Monoclonal antibodies (Mabs) have been useful for immunoscintigraphic applications in clinical diagnosis since
they were introduced in the practice of nuclear medicine. The ior egf/r3 (Centis, Cuba) is a murine monoclonal
antibody against epidermal growth factor receptor (EGF-R) and has been widely used in the radioimmunodiagnosis
of tumors of epithelial origin. Labeled with 99mTc, its main application in Nuclear Medicine is the follow up,
detection and evaluation of tumor recurrences. The objective of this work is to describe the preparation of a
lyophilized formulation (kit) for radiolabeling the Mab ior egf/r3 with 99mTc for immunoscintigraphic applications.
Radiolabeling efficiency, effects on immunoreactivity, image studies and stability of the formulation are reported.
The study demonstrated that the kit formulation can be labeled with 99mTc at high yields and can be used to
visualize in vivo human tumors of epithelial origin by immunoscintigraphy studies.
Como referenciar
DIAS, C.R.; MARCZEWSKI, B.; MORAES, V.; BARBOZA, M.F.; OSSO JUNIOR, J.A. Tc-sup(99m) direct radiolabeling of monoclonal antibody I or egf/r3: quality control and image studies in mice. Brazilian Archives of Biology and Technology, v. 48, p. 29-35, 2005. n.esp. 2. DOI: 10.1590/S1516-89132005000700004. Disponível em: http://repositorio.ipen.br/handle/123456789/5507. Acesso em: 23 Feb 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.