Tc-sup(99m) direct radiolabeling of monoclonal antibody I or egf/r3: quality control and image studies in mice

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dc.contributor.authorDIAS, C.R.pt_BR
dc.contributor.authorMARCZEWSKI, B.pt_BR
dc.contributor.authorMORAES, V.pt_BR
dc.contributor.authorBARBOZA, M.F.pt_BR
dc.contributor.authorOSSO JUNIOR, J.A.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2014-07-15T13:48:53Zpt_BR
dc.date.accessioned2014-07-30T11:46:54Z
dc.date.available2014-07-15T13:48:53Zpt_BR
dc.date.available2014-07-30T11:46:54Z
dc.date.issued2005pt_BR
dc.description.abstractMonoclonal antibodies (Mabs) have been useful for immunoscintigraphic applications in clinical diagnosis since they were introduced in the practice of nuclear medicine. The ior egf/r3 (Centis, Cuba) is a murine monoclonal antibody against epidermal growth factor receptor (EGF-R) and has been widely used in the radioimmunodiagnosis of tumors of epithelial origin. Labeled with 99mTc, its main application in Nuclear Medicine is the follow up, detection and evaluation of tumor recurrences. The objective of this work is to describe the preparation of a lyophilized formulation (kit) for radiolabeling the Mab ior egf/r3 with 99mTc for immunoscintigraphic applications. Radiolabeling efficiency, effects on immunoreactivity, image studies and stability of the formulation are reported. The study demonstrated that the kit formulation can be labeled with 99mTc at high yields and can be used to visualize in vivo human tumors of epithelial origin by immunoscintigraphy studies.
dc.format.extent29-35pt_BR
dc.identifier.citationDIAS, C.R.; MARCZEWSKI, B.; MORAES, V.; BARBOZA, M.F.; OSSO JUNIOR, J.A. Tc-sup(99m) direct radiolabeling of monoclonal antibody I or egf/r3: quality control and image studies in mice. <b>Brazilian Archives of Biology and Technology</b>, v. 48, p. 29-35, 2005. n.esp. 2. DOI: <a href="https://dx.doi.org/10.1590/S1516-89132005000700004">10.1590/S1516-89132005000700004</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/5507.
dc.identifier.doi10.1590/S1516-89132005000700004
dc.identifier.issn1516-8913pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6672-1631
dc.identifier.suplementon.esp. 2pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/5507pt_BR
dc.identifier.vol48
dc.relation.ispartofBrazilian Archives of Biology and Technologypt_BR
dc.rightsopenAccessen
dc.subjectmonoclonal antibodiespt_BR
dc.subjecttechnetium 99pt_BR
dc.subjectlabellingpt_BR
dc.subjectradiopharmaceuticalspt_BR
dc.subjectnuclear medicinept_BR
dc.subjectimmunitypt_BR
dc.subjectscintiscanningpt_BR
dc.subjectlyophilizationpt_BR
dc.titleTc-sup(99m) direct radiolabeling of monoclonal antibody I or egf/r3: quality control and image studies in micept_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorVANESSA MORAES
ipen.autorJOAO ALBERTO OSSO JUNIOR
ipen.autorMARYCEL ROSA FELISA FIGOLS DE BARBOZA
ipen.autorBARBARA SZOT MARCZEWSKI
ipen.autorCARLA ROBERTA DE BARROS RODRIGUES DIAS
ipen.codigoautor2619
ipen.codigoautor140
ipen.codigoautor1236
ipen.codigoautor2705
ipen.codigoautor2715
ipen.contributor.ipenauthorVANESSA MORAES
ipen.contributor.ipenauthorJOAO ALBERTO OSSO JUNIOR
ipen.contributor.ipenauthorMARYCEL ROSA FELISA FIGOLS DE BARBOZA
ipen.contributor.ipenauthorBARBARA SZOT MARCZEWSKI
ipen.contributor.ipenauthorCARLA ROBERTA DE BARROS RODRIGUES DIAS
ipen.date.recebimento06-01pt_BR
ipen.identifier.fi0.131pt_BR
ipen.identifier.ipendoc11183pt_BR
ipen.range.fi0.001 - 1.499
ipen.type.genreArtigo
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relation.isAuthorOfPublication8564086d-e872-4c3a-a622-a76a8fba0069
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relation.isAuthorOfPublication.latestForDiscoveryc8caef90-0b8a-4c08-bcec-cd3f72419253
sigepi.autor.atividadeDIAS, C.R.:2715:12:Spt_BR
sigepi.autor.atividadeMARCZEWSKI, B.:2705:12:Npt_BR
sigepi.autor.atividadeMORAES, V.:2619:12:Npt_BR
sigepi.autor.atividadeBARBOZA, M.F.:1236:12:Npt_BR
sigepi.autor.atividadeOSSO JUNIOR, J.A.:140:12:Npt_BR
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