CARLA ROBERTA DE BARROS RODRIGUES DIAS

CARLA ROBERTA DE BARROS RODRIGUES DIAS

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Status report on thechnical progress for LEU-based sup(99)Mo production at IPEN-CNEN/SP, Brazil - Modified Cintichem process
2015 - OSSO JUNIOR, J.A.; DIAS, C.R.B.R.; TEODORO, R.; CATANOSO, M.F.; BRAMBILLA, T.P.; POZZO, L.; SQUAIR, P.; FUKUMORI, N.; CARVALHO, F.M.S.; ZINI, J.; CAMILO, R.L.; FORBICINI, C.; YAMAMURA, M.; ARAUJO, I.C.; FREITAS, A.A.; CARVALHO, E.U.; DURAZZO, M.; SILVA, A.M.; PIRES, M.A.; MARUMO, J.T.; DELLAMANO, J.C.; MENGATTI, J.; PERROTTA, J.A.
Brazilian strategies to overcome molybdenum crisis: present and future perspectives of the multipurpose research reactor
2011 - OSSO JUNIOR, J.A.; TEODORO, R.; DIAS, C.R.B.R.; BEZERRA, R.R.L.; VILLELA, L.A.; CORREIA, J.L.; PERROTTA, J.A.; PEREIRA, G.A.; ZAPPAROLI JUNIOR, C.L.; MENGATTI, J.
Determination of gamma emitting radionuclidc impurities of sup(99)Mo produced by nuclear fission of sup(235)U
2014 - SAID, DAPHNE de S.; DIAS, CARLA R. de B.R.; ZINI, JOSIANE; BRAMBILLA, TANIA de P.; OSSO JUNIOR, JOAO A.
Radiolabeling of anti-cd20 with Re-188: liquid kit
2007 - DIAS, CARLA R.; OSSO JUNIOR, JOAO A.
Radioimmunotherapy uses the targeting features of monoclonal antibody to deliver radiation from an attached radionuclide. The radionuclide 188Re is currently produced from the father nuclide 188W through a transportable generator system. Because of its easy availability and suitable nuclear properties (EβMAX =2.1 MeV, t1/2=16.9 h, Eγ=155 keV), this radionuclide is considered an attractive candidate for application as therapeutic agents and could be conveniently utilized for imaging and dosimetric purposes. The objective of this work is the optimization of radiolabeling of anti-CD20 with 188Re using a liquid formulation. Anti-CD20 was reduced by incubation with 2-ME and purified over a PD-10 column. The number of resulting free SH was assayed with Ellman’s reagent. Optimization of radiolabeling was achieved by varying parameters: antibody mass, reducing agent, reaction time and 188Re volume in the liquid kit. Radiochemical purity of 188Re-anti-CD20 was evaluated. An average of 12 SH groups per mol in the reductions was found. The best labeling efficiency (> 93%) was achieved in the following conditions: 1 mg anti-CD20; 82.8 mg sodium tartrate; 1 mg SnCl2; 0.25 mg gentisic acid, 1 mL 188Re and reaction time of 1 hour at room temperature.
Analise da imunorreatividade do anticorpo monoclonal anti-CEA IOR-1 marcado com sup(99m)Tc
2002 - DIAS, C.R.B.R.; HERRERIAS, R.; PIRES, J.A.; BERNARDES, D.M.L.; FIGOLS de BARBOZA, M.R.F.; SILVA, C.P.G.
Production of sup(99)Mo at IPEN-CNEN/SP-Brazil
2013 - OSSO JUNIOR, JOAO A.; DIAS, CARLA R.B.R.; BRAMBILLA, TANIA P.; TEODORO, RODRIGO; CATANOSO, MARCELA F.; ZINI, JOSIANE; BEZERRA, REGINA R.L.; VILLELA, LUIZ A.; CORREIA, JEREMIAS L.; IVANOV, EVANDRO; CARVALHO, FATIMA M.S.; POZZO, LORENA; SQUAIR, PETERSON L.; MENGATTI, JAIR
Testes de controle de qualidade em calibradores de dose utilizados em laboratórios de pesquisa do IPEN
2013 - KUAHARA, LILIAN T.; MARTINS, ELAINE W.; DIAS, CARLA R.; CORREA, EDUARDO de L.; POTIENS, MARIA da P.A.; JUNIOR, AMAURY C.R.
Radiolabeling of anti-CD20 with Re-188 treatment of non-hodgkin's lymphoma: radiochemical control
2009 - DIAS, CARLA R.; OSSO JUNIOR, JOAO A.
Cintichem modified process sup(99)Mo precipitation step: application of statistical analysis tools over the reactional parameters
2011 - TEODORO, RODRIGO; DIAS, CARLA R.B.R.; FERNANDEZ NUNEZ, EUTIMIO G.; OSSO JUNIOR, JOAO A.
Comparison between a commercial solid-phase extraction cartridge and a home-made silver containing charcoal column: purification of Mo-99 from I-131 and Te-121
2011 - DIAS, CARLA R.; TEODORO, RODRIGO; OSSO JUNIOR, JOAO