BARBARA SZOT MARCZEWSKI

BARBARA SZOT MARCZEWSKI

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Caracterizacao da resposta RPE dos excipientes dos medicamentos para aplicacao em dosimetria de acidente
2002 - MARCZEWSKI, B.S.; RODRIGUES JUNIOR, O.; GALANTE, O.L.; COSTA, Z.M.; CAMPOS, L.L.
A radiopharmaceutic agent for bone pain: the chromatographic behaviour of Re-188-HEDP in dextran matrix for radiochemical quality control
2007 - MARCZEWSKI, BARBARA; DIAS, CARLA R.; OSSO JUNIOR, JOAO A.
Estudos de marcação do etidronato com sup(188)Re proveniente de diferentes gerações de sup(188)W/sup(188)Re
2006 - MARCZEWSKI, BARBARA S.
O interesse pelo 188Re para aplicações terapêuticas na medicina nuclear é devido à meia-vida de 16,9 horas, emissão de partículas βֿ com energia máxima de 2,12 MeV e raios-γ de 155 keV adequados para a aquisição de imagens. O estudo apresenta a radiomarcação do HEDP (etidronato) com o 188Re eluído de geradores de 188W/188Re a base de Al2O3 e tipo-gel 188WZr. A dependência do rendimento do 188Re-HEDP na concentração do agente redutor, pH, tempo de reação, temperatura e adição de carregador Re2O7 foram avaliados. A partir das condições ótimas de marcação os rendimentos do 188Re-HEDP foram ≥ 98% tanto para os kits líquidos como liofilizados. A formulação padrão que representou esses resultados contém: 30 mg de HEDP, 7 mg de SnCl2, 3 mg de ácido ascórbico e adição de 20 μg de Re2O7. As reações foram conduzidas sob aquecimento de 100 °C por 30 minutos, seguidos de 60 minutos de incubação. Outro aspecto importante do trabalho foi o controle de qualidade radioquímico, comparando os resultados de CP, CCD e cromatografia iônica, além dos experimentos com a CLAE. A distribuição biológica realizada comprovou a captação pelo esqueleto e a estabilidade in vivo dos complexos de 188Re-HEDP.
Study of preparation of generators of 99 Mo-99mTc based to gels of molybdenum with zirconium, titanium, cerum and hafnium
2006 - MORAES, VANESSA; MARCZEWSKI, BARBARA; DIAS, CARLA R.; MARTINS, PATRICIA de A.; OSSO JUNIOR, JOAO A.
Tc-99m direct radiolabeling of monoclonal antibodies: reducing and purification of antibodies
2006 - DIAS, CARLA R.; BARBOZA, MARYCEL F. de; MORAES, VANESSA; MARCZEWSKI, BARBARA; OSSO JUNIOR, JOAO A.
Liquid kit for preparation of sup(188) rhenium-etidronate
2005 - MARCZEWSKI, B.; DIAS, C.R.; MORAES, V.; OSSO JUNIOR, J.A.
The aim of this study was the preparation of a liquid kit for radiolabeling of 188Re-HEDP (hydroxyethylidene diphosphonate). 188Re was obtained from alumina based 188W/ 188Re generators. This paper reports the efficacy of a cold kit stored for more than two weeks, determined by the dependence of the radiolabeling yields of 188Re-HEDP on the incubation time, reducing agent concentration, the effects of concentration of ligand, the pH of the reaction and the temperature. The cold kits showed a good stability when carrie-free rhenium-188 was added in the reaction mixture.
Study of gels of molybdenum with cerium in the preparation of generators of sup(99)Mo - sup(99m)Tc
2005 - MORAES, V.; MARCZEWSKI, B.; DIAS, C.R.; OSSO JUNIOR, J.A.
99m Tc has ideal nuclear properties for organ imaging in nuclear medicine, and it is obtained from the 99Mo99m Tc generator. Four different types of generators are available: chromatographic that uses 99Mo from fission of uranium; MEK solvent extraction; Tc2O7 sublimation; gel chromatographic. This work presents the preparation of gel generators of molybdenum with cerium and characterization of the gels: mass ratio between molybdenum and cerium, structure, size of particles and elution percentage of 99m Tc after irradiating the gels. Eight gels were prepared at the same temperature of 50 ºC with concentrations of NaOH of 2 and 4 mol/L, mass ratio of 0.31 and 0.38 and final pH of 3.5 and 4.5. The analysis of the results proved that these gels are not adequate for preparation of the generators of 99Mo99m Tc, since the elution percentages are low, when compared with the gel of molybdenum with zirconium.
Tc-sup(99m) direct radiolabeling of monoclonal antibody I or egf/r3: quality control and image studies in mice
2005 - DIAS, C.R.; MARCZEWSKI, B.; MORAES, V.; BARBOZA, M.F.; OSSO JUNIOR, J.A.
Monoclonal antibodies (Mabs) have been useful for immunoscintigraphic applications in clinical diagnosis since they were introduced in the practice of nuclear medicine. The ior egf/r3 (Centis, Cuba) is a murine monoclonal antibody against epidermal growth factor receptor (EGF-R) and has been widely used in the radioimmunodiagnosis of tumors of epithelial origin. Labeled with 99mTc, its main application in Nuclear Medicine is the follow up, detection and evaluation of tumor recurrences. The objective of this work is to describe the preparation of a lyophilized formulation (kit) for radiolabeling the Mab ior egf/r3 with 99mTc for immunoscintigraphic applications. Radiolabeling efficiency, effects on immunoreactivity, image studies and stability of the formulation are reported. The study demonstrated that the kit formulation can be labeled with 99mTc at high yields and can be used to visualize in vivo human tumors of epithelial origin by immunoscintigraphy studies.