JOAO ALBERTO OSSO JUNIOR

(Fonte: Lattes)
Resumo

Possui graduação em Química pela Universidade de São Paulo (1978), mestrado em Engenharia Nuclear pela Universidade Federal do Rio de Janeiro (1982) e doutorado em Ph D em Química Nuclear - University of Manchester (1986). Atualmente é pesquisador da Comissão Nacional de Energia Nuclear, revisor dos journals - Brazilian Archives of Biology and Technology, - Applied Radiation and Isotopes e professor pós-graduação da Universidade de São Paulo. Tem experiência na área de Engenharia Nuclear, com ênfase em Produção de Radioisótopos, atuando principalmente nos seguintes temas: medicina nuclear, tecnecio-99m, gerador tipo gel, reator nuclear e ciclotron. (Texto extraído do Currículo Lattes em 8 maio 2023)

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Agora exibindo 1 - 3 de 3
  • Artigo IPEN-doc 15116
    Tissue distribution of radiolabeled phosphatidylserine containing liposome in mice
    2009 - BORBOREMA, SAMANTA E.T.; ANDRADE JUNIOR, HEITOR F.; OSSO JUNIOR, JOAO A.; NASCIMENTO, NANCI
  • Artigo IPEN-doc 11941
    Pharmacokinetic of antimony in mice with cutaneous leishmaniasis
    2007 - BORBOREMA, SAMANTA E.T.; ANDRADE JUNIOR, HEITOR F. de; OSSO JUNIOR, JOAO A.; NASCIMENTO, NANCI do
  • Artigo IPEN-doc 11180
    In vitro antileishmanial properties of neutron-irradiated meglumine antimoniate
    2005 - BORBOREMA, S.E.T.; ANDRADE JUNIOR, H.F.; OSSO JUNIOR, J.A.; NASCIMENTO, N.
    Pentavalent antimony, as meglumine antimoniate (Glucantime) or sodium stibogluconate (Pentostam), is the main treatment for leishmaniasis, a complex of diseases caused by the protozoan Leishmania, and an endemic and neglected threat in Brazil. Despite over half a century of clinical use, their mechanism of action, toxicity and pharmacokinetic data remain unknown. The analytical methods for determination of antimony in biological systems remain complex and have low sensitivity. Radiotracer studies have a potential in pharmaceutical development. The aim of this study was to obtain a radiotracer for antimony, with suitable physical and biological properties. Meglumine antimoniate was neutron irradiated inside the IEA-R1 nuclear reactor, producing two radioisotopes 122Sb and 124Sb, with high radionuclidic purity and good specific activity. This compound showed the same antileishmanial activity as the native compound. The use of the radiotracers, easily created by neutron irradiation, could be an interesting tool to solve important questions in antimonial pharmacology.