In vitro antileishmanial properties of neutron-irradiated meglumine antimoniate
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2005
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Brazilian Archives of Biology and Technology
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Resumo
Pentavalent antimony, as meglumine antimoniate (Glucantime) or sodium stibogluconate (Pentostam), is the
main treatment for leishmaniasis, a complex of diseases caused by the protozoan Leishmania, and an endemic and
neglected threat in Brazil. Despite over half a century of clinical use, their mechanism of action, toxicity and
pharmacokinetic data remain unknown. The analytical methods for determination of antimony in biological systems
remain complex and have low sensitivity. Radiotracer studies have a potential in pharmaceutical development. The
aim of this study was to obtain a radiotracer for antimony, with suitable physical and biological properties.
Meglumine antimoniate was neutron irradiated inside the IEA-R1 nuclear reactor, producing two radioisotopes
122Sb and 124Sb, with high radionuclidic purity and good specific activity. This compound showed the same
antileishmanial activity as the native compound. The use of the radiotracers, easily created by neutron irradiation,
could be an interesting tool to solve important questions in antimonial pharmacology.
Como referenciar
BORBOREMA, S.E.T.; ANDRADE JUNIOR, H.F.; OSSO JUNIOR, J.A.; NASCIMENTO, N. In vitro antileishmanial properties of neutron-irradiated meglumine antimoniate. Brazilian Archives of Biology and Technology, v. n.esp. 2, n. 48, p. 63-67, 2005. DOI: 10.1590/S1516-89132005000700009. Disponível em: http://repositorio.ipen.br/handle/123456789/5510. Acesso em: 17 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.