In vitro antileishmanial properties of neutron-irradiated meglumine antimoniate

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dc.contributor.authorBORBOREMA, S.E.T.pt_BR
dc.contributor.authorANDRADE JUNIOR, H.F.pt_BR
dc.contributor.authorOSSO JUNIOR, J.A.pt_BR
dc.contributor.authorNASCIMENTO, N.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2014-07-15T13:48:55Zpt_BR
dc.date.accessioned2014-07-30T11:46:15Z
dc.date.available2014-07-15T13:48:55Zpt_BR
dc.date.available2014-07-30T11:46:15Z
dc.date.issued2005pt_BR
dc.description.abstractPentavalent antimony, as meglumine antimoniate (Glucantime) or sodium stibogluconate (Pentostam), is the main treatment for leishmaniasis, a complex of diseases caused by the protozoan Leishmania, and an endemic and neglected threat in Brazil. Despite over half a century of clinical use, their mechanism of action, toxicity and pharmacokinetic data remain unknown. The analytical methods for determination of antimony in biological systems remain complex and have low sensitivity. Radiotracer studies have a potential in pharmaceutical development. The aim of this study was to obtain a radiotracer for antimony, with suitable physical and biological properties. Meglumine antimoniate was neutron irradiated inside the IEA-R1 nuclear reactor, producing two radioisotopes 122Sb and 124Sb, with high radionuclidic purity and good specific activity. This compound showed the same antileishmanial activity as the native compound. The use of the radiotracers, easily created by neutron irradiation, could be an interesting tool to solve important questions in antimonial pharmacology.
dc.format.extent63-67pt_BR
dc.identifier.citationBORBOREMA, S.E.T.; ANDRADE JUNIOR, H.F.; OSSO JUNIOR, J.A.; NASCIMENTO, N. In vitro antileishmanial properties of neutron-irradiated meglumine antimoniate. <b>Brazilian Archives of Biology and Technology</b>, v. n.esp. 2, n. 48, p. 63-67, 2005. DOI: <a href="https://dx.doi.org/10.1590/S1516-89132005000700009">10.1590/S1516-89132005000700009</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/5510.
dc.identifier.doi10.1590/S1516-89132005000700009
dc.identifier.fasciculo48
dc.identifier.issn1516-8913pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6672-1631
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/5510pt_BR
dc.identifier.voln.esp. 2pt_BR
dc.relation.ispartofBrazilian Archives of Biology and Technologypt_BR
dc.rightsopenAccessen
dc.subjectprotozoapt_BR
dc.subjectparasitespt_BR
dc.subjectdiseasespt_BR
dc.subjecttracer techniquespt_BR
dc.subjectneutronspt_BR
dc.subjectirradiationpt_BR
dc.subjectiear-1 reactorpt_BR
dc.subjectantimony 122pt_BR
dc.subjectantimony 124pt_BR
dc.subjectphysical propertiespt_BR
dc.titleIn vitro antileishmanial properties of neutron-irradiated meglumine antimoniatept_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorNANCI DO NASCIMENTO
ipen.autorJOAO ALBERTO OSSO JUNIOR
ipen.autorSAMANTA ETEL TREIGER BORBOREMA
ipen.codigoautor411
ipen.codigoautor140
ipen.codigoautor3208
ipen.contributor.ipenauthorNANCI DO NASCIMENTO
ipen.contributor.ipenauthorJOAO ALBERTO OSSO JUNIOR
ipen.contributor.ipenauthorSAMANTA ETEL TREIGER BORBOREMA
ipen.date.recebimento06-01pt_BR
ipen.identifier.fi0.131pt_BR
ipen.identifier.ipendoc11180pt_BR
ipen.range.fi0.001 - 1.499
ipen.type.genreArtigo
relation.isAuthorOfPublication53eed426-0bd7-4230-8b8c-f48795fad345
relation.isAuthorOfPublicationb0d5c854-8fcb-4e5f-b1c9-73e82c9ca844
relation.isAuthorOfPublication1dfe7126-d43b-4783-8093-9a1db0e81f97
relation.isAuthorOfPublication.latestForDiscovery1dfe7126-d43b-4783-8093-9a1db0e81f97
sigepi.autor.atividadeBORBOREMA, S.E.T.:3208:19:Spt_BR
sigepi.autor.atividadeOSSO JUNIOR, J.A.:140:12:Npt_BR
sigepi.autor.atividadeNASCIMENTO, N.:411:19:Npt_BR
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