PAULO FLAVIO DE MACEDO GOUVEA
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Resumo IPEN-doc 24564 Osteoarthritis clinical evaluation in patients treated with peruãbe black mud, chemical and radiological characterization and establishment of good practices protocols for the peloid obtainment and use2017 - GOUVEA, P.F.M.; SILVA, P.S.C.Mudtherapy is the use of peloide (sludge, saline slime and mud) for therapeutic purposes. Although widely used worldwide its therapeutic mechanisms are not fully understood, especially considering the different origins and compositions of the used materials. Several hypotheses have been raised in the attempt to clarify such mechanisms. Peruãbe Black Mud (PBM) has traditionally been used in the treatment of osteoarthritis of the knee, which is one of the pathologies of high prevalence and great impairment of the functional capacity of the patients, through applications of the peloid in its natural form. This study intends to verify the therapeutic efficacy of mud, after undergoing a process of decontamination and maturation in marine water, in patients with knee osteoarthritis, as well as to make a comparison between the therapeutic effects of the PBM matured and that sterilized by gamma radiation after maturation. Patients aged between 30 and 85 years, divided into two groups of 20 and 21, respectively, were followed up for a period of 15 weeks. The method of observation was the double blind. The evaluation was based on subjective information collected by the WOMAC and SF36 questionnaires as well as X-ray examinations. Simultaneously, analyzes of the chemical, radiological and microbiological composition of the PBM were carried out, aiming at a systematized knowledge of the characteristics of the peloid in relation to possible deleterious effects on human health. X-ray fluorescence, neutron activation analysis, gamma spectrometry, elemental analysis, cooling kinetics studies and reduction potential were used to perform these characterizations. The results obtained allow us to conclude that PBM presents high levels of Si and S and low levels of Ca, Mg and radioactive elements. None of the samples matured or irradiated after maturation showed contamination by total coliforms, thermally tolerant coliforms or staphyloccocus aureus. The results indicate that there was a decrease in WOMAC and SF36 questionnaire scores for patients who completed the treatment.Resumo IPEN-doc 24545 Chemical characterization of the clay deposit known as peruvian black mud2017 - ALVES, I.C.; GOUVEA, P.F.M.; SILVA, P.S.C.In Peruíbe city, state of São Paulo, the largest continuous natural deposit of clay in the world can be found, containing of a material popularly known as Peruíbe Black Mud (PBM). This deposit has 83 thousand tons with a depth of 75m, distributed in 5 hectares, making the municipality a tourist point. This sludge is characterized by large amounts of fine particles, high organic matter content, high sulfite reducing bacteria content and a consequent high ion reduction potential; it is used in psoriasis, peripheral dermatitis, acne and seborrhea treatments, as well as in myalgias, arthritis and non-rheumatic joint processes. Ten samples of the in natura mud were collected along the deposit, in depth ranging from 1 to 1.5m and also 6 samples that were matured with see water, with the objective of verifying the homogeneity of the chemical composition through the evaluation of its elemental content, for the physical-chemical characterization, measurements of pH, moisture, organic matter and loss on ignition were made. The elemental concentrations were determined by neutron activation analysis. In these measurements approximately 100mg of sample were irradiated together with certified reference materials, for a period of 8 hours under a neutron flux in the order of 1012 n cm2 s1. The activities were determined by gamma spectrometry using high-purity Ge detectors. Both, in natura and maturated samples presented similar coefficient of variation for most of the elements, with Ca, Co, Cr, Cs, Fe, La, Th and U having a coefficient of variation lower than 30%, the elements As, Sm, Tb, Zn and Zr presented a coefficient of variation between 30 and 60% and the elements K, Nd, Sb, Se, Tb and Yb presented the highest coefficients of variation, above 60%.