KARINA DE OLIVEIRA GONÇALVES

KARINA DE OLIVEIRA GONÇALVES

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Sustainable synthesis of cobalt nanoparticles for supercapacitors application
2024 - DUARTE, M.; FOO, CHOO T.; OLIVEIRA, K.; SILVA, D.V. da; FARIA JUNIOR, R.N.; SAKATA, S.K.
Characterization and antibacterial activity of a nickel nanocomposite based on graphene
2024 - DUARTE, M.; GONCALVES, K.O.; SAKATA, S.K.
Effects of gamma radiation on biopolymer processed by 3D printing
2024 - GONCALVES, KARINA de O.; ALMEIDA JUNIOR, JOSE N. de; DIAS, DJALMA B.; JUNIOR, ORLANDO R.; SAKATA, SOLANGE K.
Synergizing immune balance
2024 - TEIXEIRA, BRUNA H.; GONCALVES, KARINA de O.; VIEIRA, DANIEL P.; COURROL, LILIA C.
The multifaceted health benefits of curcumin (Curcuma longa), attributed to its antioxidant, antitumor, and anti-inflammatory activities, have drawn significant scientific attention. Curcumin shows promise as a potential modulator of macrophage polarization, offering a natural strategy for managing inflammation and promoting tissue repair. However, a limiting factor for this beneficial molecule is its limited bioavailability due to its low solubility in water. This study aimed to quantify the effect of curcumin gold nanoparticle (CurAuNP)-mediated ultrasound irradiation on THP-1-derived macrophages as potential therapeutic targets. The photoreduction method was applied to synthesize the gold nanoparticles with curcumin as a ligand (CurAu). The effect of adding polyethylene glycol in the synthesis process was studied (CurAuPEG). CurAuNP characterization included UV/Vis, Zeta potential, transmission electron microscopy, and FTIR. The amount of singlet oxygen released by curcumin and CurAuNPs was quantified by observing 1.3-diphenylisobenzofuran quenching upon ultrasound irradiation (1 MHz and 1 W/cm2). The results indicated that ultrasound therapy for 4 min with CurAuNPs significantly enhanced singlet oxygen generation and reduced macrophage viability compared to curcumin alone. The increased sonoluminescence and curcumin delivery facilitated by CurAuNPs led to greater curcumin activation. Consequently, CurAuNPs could offer promising therapeutic options for modulating macrophage polarization in pro-inflammatory and anti-inflammatory stages.
Synthesis and characterization of aminolevulinic acid with gold and iron nanoparticles by photoreduction method for non‑communicable diseases diagnosis and therapy
2019 - GONÇALVES, KARINA de O.; SILVA, FLAVIA R. de O.; VIEIRA, DANIEL P.; COURROL, LILIA C.
Non-communicable diseases (NCDs) are a group of chronic diseases resulted by genetic, epigenetic and environmental factors and life style. The main types of NCDs are cardiovascular diseases and cancers. Some of therapeutic treatments for NCDs induce severe cytotoxicity to normal cells. New treatments as photodynamic and sonodynamic therapies have been proposed trying to improve the cure rate and reduce the side-effects. In these treatments certain drugs as porphyrins precursors associated to metal nanoparticles (MNPs) have become of extreme interest since have high targeting ability and potentiality to destroy tumor tissues. MNPs can induce cell death through various processes, including reactive oxygen species (ROS) generation and DNA damage, among others. In this work, we describe synthesis of MNPs by photoreduction with aminolevulinic acid (ALA), a protoporphyrin IX precursor. To obtain ALA:MNPs (M = Au or/and Fe), ALA, polyethylene glycol, and Tetrachloroauric acid and/or iron powder water solutions were irradiated by Xenon lamp. The UV–vis spectra, transmission electron microscopy and zeta potential were measured to characterize nanoparticles. The proposed mechanism of nanoparticle formation was described from a physicochemical perspective. The THP-1 macrophages cytotoxicity was determined, and photodynamic therapy (PDT) with high power LED at 590 nm for 2 min were performed. The results have suggested that the gold/iron nanoparticles interfere in the selectivity of iron transport across the mitochondrial inner membrane and enhance the effectiveness of the PDT acting as important agent for NCDs control.
Preparation and optimization of aminolevulinic acid with gold nanoparticles for photothermal and photodynamic therapies applications
2015 - GONCALVES, KARINA de O.; CORDEIRO, THIAGO da S.; SILVA, FLAVIA R. de O.; SAMAD, RICARDO E.; VIEIRA JUNIOR, NILSON D.; COURROL, LILIA C.
Aminolevulinic acid with gold nanoparticles: a novel theranostic agent for atherosclerosis
2015 - GONCALVES, KARINA de O.; SILVA, MONICA N. da; SICCHIERI, LETICIA B.; SILVA, FLAVIA R. de O.; MATOS, RICARDO A. de; COURROL, LILIA C.