FULVIO GABRIEL CORAZZA

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Agência de fomento: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) × Assunto: iron ×

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    Artigo IPEN-doc 26075
    Silver and silver-iron nanoparticles synthesized by photoreduction for applications in cancer therapy
    2019 - GONÇALVES, KARINA de O.; COURROL, LILIA C.; CORAZZA, FULVIO; VIEIRA, DANIEL P.
    Metal nanoparticles have been extensively studied for various purposes including therapeutic applications for cancer. In this study, nanoparticles of silver and silver-iron with aminolevulinic acid (ALA) were synthesized using (ALA:AgNPs and ALA:AgFeNPs) the photoreduction method with a 300 W xenon lamp, characterized by UV/vis absorption, zeta potential, x-rays diffraction, FTIR and transmission electron microscopy. The sizes obtained were ~ 23 nm for silver and ~ 12 nm for iron. Cytotoxicity assays were performed on breast tumor cells (MCF-7) and prostate cancer cells (LNCaP). The results obtained showed that it was possible to synthesize silver and silver-iron nanoparticles by the photoreduction method, and to functionalize their surfaces with ALA, which was delivered to the cells and converted to protoporphyrin IX (PpIX).