CARLA ROBERTA DE BARROS RODRIGUES DIAS
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Capítulo IPEN-doc 22010 Status report on thechnical progress for LEU-based sup(99)Mo production at IPEN-CNEN/SP, Brazil - Modified Cintichem process2015 - OSSO JUNIOR, J.A.; DIAS, C.R.B.R.; TEODORO, R.; CATANOSO, M.F.; BRAMBILLA, T.P.; POZZO, L.; SQUAIR, P.; FUKUMORI, N.; CARVALHO, F.M.S.; ZINI, J.; CAMILO, R.L.; FORBICINI, C.; YAMAMURA, M.; ARAUJO, I.C.; FREITAS, A.A.; CARVALHO, E.U.; DURAZZO, M.; SILVA, A.M.; PIRES, M.A.; MARUMO, J.T.; DELLAMANO, J.C.; MENGATTI, J.; PERROTTA, J.A.Resumo IPEN-doc 20590 Determination of gamma emitting radionuclidc impurities of sup(99)Mo produced by nuclear fission of sup(235)U2014 - SAID, DAPHNE de S.; DIAS, CARLA R. de B.R.; ZINI, JOSIANE; BRAMBILLA, TANIA de P.; OSSO JUNIOR, JOAO A.Artigo IPEN-doc 12107 Radiolabeling of anti-cd20 with Re-188: liquid kit2007 - DIAS, CARLA R.; OSSO JUNIOR, JOAO A.Radioimmunotherapy uses the targeting features of monoclonal antibody to deliver radiation from an attached radionuclide. The radionuclide 188Re is currently produced from the father nuclide 188W through a transportable generator system. Because of its easy availability and suitable nuclear properties (EβMAX =2.1 MeV, t1/2=16.9 h, Eγ=155 keV), this radionuclide is considered an attractive candidate for application as therapeutic agents and could be conveniently utilized for imaging and dosimetric purposes. The objective of this work is the optimization of radiolabeling of anti-CD20 with 188Re using a liquid formulation. Anti-CD20 was reduced by incubation with 2-ME and purified over a PD-10 column. The number of resulting free SH was assayed with Ellman’s reagent. Optimization of radiolabeling was achieved by varying parameters: antibody mass, reducing agent, reaction time and 188Re volume in the liquid kit. Radiochemical purity of 188Re-anti-CD20 was evaluated. An average of 12 SH groups per mol in the reductions was found. The best labeling efficiency (> 93%) was achieved in the following conditions: 1 mg anti-CD20; 82.8 mg sodium tartrate; 1 mg SnCl2; 0.25 mg gentisic acid, 1 mL 188Re and reaction time of 1 hour at room temperature.Artigo IPEN-doc 19834 Production of sup(99)Mo at IPEN-CNEN/SP-Brazil2013 - OSSO JUNIOR, JOAO A.; DIAS, CARLA R.B.R.; BRAMBILLA, TANIA P.; TEODORO, RODRIGO; CATANOSO, MARCELA F.; ZINI, JOSIANE; BEZERRA, REGINA R.L.; VILLELA, LUIZ A.; CORREIA, JEREMIAS L.; IVANOV, EVANDRO; CARVALHO, FATIMA M.S.; POZZO, LORENA; SQUAIR, PETERSON L.; MENGATTI, JAIRResumo IPEN-doc 18953 Preliminary studies of modified CINTICHEM sup(99)Mo production process at IPEN/CNEN-SP precipitation step2011 - TEODORO, RODRIGO; DIAS, CARLA R.B.R.; OSSO JUNIOR, JOAO A.